CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Pharmacy degree from Universidade de São Paulo (1990) and Ph.D. in Chemistry from Universidade Federal de São Carlos (1997). Pos-doctoral fellow at USP (1996-1997) and Harvard Medical School (2006-2007). Professor of Medicinal Chemistry and Natural Products at Pharmacy School at Ribeirao Preto, Universidade de Sao Paulo (FCFRP-USP), since 1998. In 2009 was promoted to Associate Professor position and in 2019 to Full Professor. She served as Associate editor of Journal of the Brazilian Chemical Society and Scientific Reports. Currently she is editor of mSystems and Brazilian Journal of Pharmacognosy. She is currently the coordinator of the first ICBG in Brazil, together with Jon Clardy. This initiative is supported by the FIC-NIH and FAPESP. She served as president of Graduate Studies Committee (CPG) at FCFRP-USP during 2018-2022. Currently, she is Deputy Director of FCFRP-USP (2022-2026). She has experience in the Chemistry of Natural Products, with emphasis in the following subjects: symbiont microorganisms, natural products, chemical ecology of interspecies interactions. http://pupolab.fcfrp.usp.br/ Instagram: @PupoLab.LQMo (Source: Lattes Curriculum)
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The lack of robustly validated drug targets has proved a significant barrier to the discovery of new treatments for visceral leishmaniasis and Chagas' disease. Furthermore, target deconvolution studies with active leads emerging from current small molecule phenotypic screening have confirmed that the same relatively few molecular targets are being hit repeatedly. This project aims to ad…
Modern tools have enabled a revolution in the derivation of therapeutic products from the study of metabolic symbionts. Some of the most complex and promising metabolic symbionts belong to the insect order Hemiptera which include successful plant-pests (e.g. aphids, etc.) and human blood-feeders (e.g. kissing bugs - the Chagas vector). The most complex Hemipteran symbiosis occurs in the i…
An International Cooperative Biodiversity Group (ICBG) with an interdisciplinary leadership team of physicians, pharmacologists, evolutionary biologists, and chemists will discover and develop therapeutic agents produced by Brazilian symbiotic bacteria. The team will target three therapeutic areas: 1) infectious fungal pathogens, 2) Chagas disease and leishmaniasis, and 3), cancers of the…
Natural products may be a result from the interaction among different organisms. Recent studies with bacterial symbionts have demonstrated that these microorganims can be the real producers of compounds isolated from the symbionts macroorganisms. These researches also have shown that natural products can act as regulators of complex ecological interactions. In fact, the existent literatur…
(Only some records are available in English at this moment)
Natural products play an important role in the discovery of bioactive compounds, helping in the process of developing new drugs. In this context, microorganisms have a remarkable contribution, since many bioactive compounds are biosynthesized by them. It is known that throughout evolution social insects have established symbiotic relationships with microorganisms, these relationships are …
Attine ants have as a behavioral feature, the cultivation of "fungal gardens" for nutritional purposes. However, the integrity of the colonies can be compromised when the growth of Escovopsis fungus is observed, which is a specialized parasite of these gardens. One of the strategies to protect colonies is the establishment of a symbiotic relationship with actinobacteria, mainly of the gen…
Neglected tropical diseases (NTDs) affect more than 1 billion people under poverty conditions in underdeveloped and developing countries. Among the NTDs, Chagas disease and Human African trypanosomiasis (HAT) are the 13 most widespread diseases in the world caused by protozoa. Since the conventional medicaments to treat these diseases are toxic or cause severe adverse reactions, a search …
Neglected Tropical Diseases (NTDs) are a set of diseases strongly present in developing countries, with precarious access to health and basic sanitation systems, prevalent in tropical and subtropical regions. Although there are programs for the prevention and eradication of NTDs, such as Chagas Disease and Leishmaniasis, few drugs are available for treatment, with relevant adverse reactio…
Natural products play an important role in the discovery of new bioactive compounds, inspiring the development of new drugs. In this context, the microorganisms have a remarkable contribution since they are capable of produce several active secondary metabolites against different pathogens. For this reason, the association with microorganisms proved to be an important evolutionary advanta…
(Only some records are available in English at this moment)
Trypanosomiasis (Chagas disease and Human African trypanosomiasis -HAT) are the most serious of tropical neglected diseases, affecting 6 to 7 million people in poverty conditions in Latin America and endemic in 36 sub-Saharan Africa countries. Chagas disease and HAT are caused by protozoan parasites from the genus Trypanosoma whose vectors are Triatominae (kissing bugs) in Latin America a…
The ants of the Attini tribe have developed over time a relationship of domestication and later mutualism with Basidiomycete fungi, which are grown in fungal gardens and serve as the main food source of these ants. Several microorganisms can parasitize the colonies of these farmer insects, and the ants have created physical and chemical defense mechanisms against these invaders. However, …
Microorganisms associated with social insects have been extensively studied as sources of new chemical structures with antimicrobial activity; however, there are no reports in the literature about the secondary metabolites produced by microorganisms associated with the Cecropia-Azteca interaction. In an ongoing PhD project, seven strains of actinobacteria were isolated from Cecropia-Aztec…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 9 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 54 / 40 | Completed scholarships in Brazil |
| 10 / 10 | Completed scholarships abroad |
| 77 / 60 | All research grants and scholarships |
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