CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Pharmacy degree from Universidade de São Paulo (1990) and Ph.D. in Chemistry from Universidade Federal de São Carlos (1997). Pos-doctoral fellow at USP (1996-1997) and Harvard Medical School (2006-2007). Professor of Medicinal Chemistry and Natural Products at Pharmacy School at Ribeirao Preto, Universidade de Sao Paulo (FCFRP-USP), since 1998. In 2009 was promoted to Associate Professor position and in 2019 to Full Professor. She served as Associate editor of Journal of the Brazilian Chemical Society, Scientific Reports, mSystems and guest editorial member of Frontiers in Microbiology and Annual Review of Microbiology. Currently she is part of the Editorial Board of Brazilian Journal of Pharmacognosy. She has coordinated the first ICBG in Brazil, together with Jon Clardy. This initiative was supported by the FIC-NIH and FAPESP (2014-2020). She served as president of Graduate Studies Committee (CPG) at FCFRP-USP during 2018-2022. Currently, she is Deputy Director of FCFRP-USP (2022-2026). She has experience in the Chemistry of Natural Products, with emphasis in the following subjects: symbiont microorganisms, natural products, chemical ecology of interspecies interactions. http://pupolab.fcfrp.usp.br/ Instagram: @PupoLab.LQMo (Source: Lattes Curriculum)
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The lack of robustly validated drug targets has proved a significant barrier to the discovery of new treatments for visceral leishmaniasis and Chagas' disease. Furthermore, target deconvolution studies with active leads emerging from current small molecule phenotypic screening have confirmed that the same relatively few molecular targets are being hit repeatedly. This project aims to ad…
Modern tools have enabled a revolution in the derivation of therapeutic products from the study of metabolic symbionts. Some of the most complex and promising metabolic symbionts belong to the insect order Hemiptera which include successful plant-pests (e.g. aphids, etc.) and human blood-feeders (e.g. kissing bugs - the Chagas vector). The most complex Hemipteran symbiosis occurs in the i…
An International Cooperative Biodiversity Group (ICBG) with an interdisciplinary leadership team of physicians, pharmacologists, evolutionary biologists, and chemists will discover and develop therapeutic agents produced by Brazilian symbiotic bacteria. The team will target three therapeutic areas: 1) infectious fungal pathogens, 2) Chagas disease and leishmaniasis, and 3), cancers of the…
(Only some records are available in English at this moment)
The socio-environmental impacts associated with the industrialization of agriculture since 1960 have called into questions the viability of maintaining this model to meet the world's growing demand for food. The ecosystem imbalance caused by the indiscriminate use of pesticides has made the agricultural system increasingly dependent on these products and endangered biodiversity, especiall…
Natural products, or secondary metabolites, play a pivotal role in the development of biologically active compounds and are essential for discovering new drugs with antimicrobial, anticancer, and antiparasitic activities. Microorganisms, which comprise a substantial portion of global biodiversity, are rich sources of secondary metabolites due to their complex symbiotic interactions with o…
Natural products play a crucial role in drug development due to their chemical diversity and biochemical specificity. Approximately 50% of FDA-approved drugs between 1981 and 2019 are derived from or related to natural products. However, emerging microbial resistance represents a significant challenge, necessitating the search for new compounds with antimicrobial potential. Environmental …
(Only some records are available in English at this moment)
Natural products, which are derived from plants, marine organisms, and microorganisms, are crucial for the development of new pharmaceuticals. It is estimated that approximately half of the pharmaceuticals sold originate from natural products. Microorganisms are important sources in the discovery of new pharmaceuticals, with antimicrobial and antitumor potential, among others. Furthermore…
Natural products play an important role in the discovery of bioactive compounds, helping in the process of developing new drugs. In this context, microorganisms have a remarkable contribution, since many bioactive compounds are biosynthesized by them. It is known that throughout evolution social insects have established symbiotic relationships with microorganisms, these relationships are …
Neglected Tropical Diseases (NTDs) are a set of diseases strongly present in developing countries, with precarious access to health and basic sanitation systems, prevalent in tropical and subtropical regions. Although there are programs for the prevention and eradication of NTDs, such as Chagas Disease and Leishmaniasis, few drugs are available for treatment, with relevant adverse reactio…
(Only some records are available in English at this moment)
Trypanosomiasis (Chagas disease and Human African trypanosomiasis -HAT) are the most serious of tropical neglected diseases, affecting 6 to 7 million people in poverty conditions in Latin America and endemic in 36 sub-Saharan Africa countries. Chagas disease and HAT are caused by protozoan parasites from the genus Trypanosoma whose vectors are Triatominae (kissing bugs) in Latin America a…
The ants of the Attini tribe have developed over time a relationship of domestication and later mutualism with Basidiomycete fungi, which are grown in fungal gardens and serve as the main food source of these ants. Several microorganisms can parasitize the colonies of these farmer insects, and the ants have created physical and chemical defense mechanisms against these invaders. However, …
Microorganisms associated with social insects have been extensively studied as sources of new chemical structures with antimicrobial activity; however, there are no reports in the literature about the secondary metabolites produced by microorganisms associated with the Cecropia-Azteca interaction. In an ongoing PhD project, seven strains of actinobacteria were isolated from Cecropia-Aztec…
(Only some records are available in English at this moment)
| 11 / 7 | Completed research grants |
| 7 / 7 | Ongoing scholarships in Brazil |
| 58 / 44 | Completed scholarships in Brazil |
| 10 / 10 | Completed scholarships abroad |
| 86 / 68 | All research grants and scholarships |
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