CV Lattes
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Universidade Federal do ABC (UFABC). Centro de Ciências Naturais e Humanas (CCNH) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Farmacêuticas from Faculdade de Medicina do ABC (2004), master's at Ciencias da Saude from Faculdade de Medicina do ABC (2006) and doctorate at Biochemistry from Universidade Federal de São Paulo (2011). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: erbb2, phage display, heparanase, câncer de mama and peptídeos. (Source: Lattes Curriculum)
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The clinical treatment of several hematological tumors has been revolutionized by chimeric antigen receptors T cells (CAR T) targeting antigens expressed at the surface of tumor cells to eradicate them. However, its performance is still below expectations against solid tumors, mainly due to the inefficient migration and transit of CAR T cells in these tumor sites and the frequent local im…
T cells containing chimeric receptors composed of antibody binding motifs (CAR T cells, chimeric antigen receptor T cells), capable to be directly activated when in contact with a specific antigen, are a potent new generation of cancer immunotherapy, unexploited by Brazilian researchers. Extraordinary results have been obtained using CAR T cells for the treatment of hematological tumors. …
T cells expressing chimeric antigen receptors (CAR T cells) have demonstrated remarkable clinical efficacy in treating different hematologic tumors. However, several challenges must be overcome to allow similar efficiency against solid tumors. Among these challenges, two points are remarkable: the inefficient migration of LT CAR to tumor sites and the frequent local immunosuppression that…
Glioblastoma (GBM) is the most malignant and prevalent of all brain tumors, leading to the death of most patients within a year and a half after the initial diagnosis. Hypoxia is a frequent feature of GBM that leads to the overexpression of several proteins, including carbonic anhydrase IX (CAIX). CAIX is a transmembrane metalloenzyme responsible for the reversible hydration of carbon dio…
T cell exhaustion is a process characterized by progressive loss of T cell effector functions, associated with a decrease in cell proliferation rate, overexpression, and coexpression of several inhibitory receptors, despite other metabolic changes. Several tumors overexpress molecules that promote immune checkpoint blockade as a strategy to curb the immune response against cancer, such as…
Carbonic anhydrase IX (CAIX) is an enzyme responsible for carbon dioxide hydration that is overexpressed in many hypoxic solid tumors, but not in normal tissues. Besides CAIX expression, many tumors overexpress programmed death-ligand 1 (PD-L1). PD-L1 binds to PD-1 receptor in T cells, B cells, and natural killer, resulting in an anergic phenotype of these cells that cannot restrain tumor…
| 1 / 1 | Ongoing grants |
| 4 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 2 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 9 / 7 | All research grants and scholarships |
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