Abstract
The cytosolic enzyme Cu,Zn-superoxide dismutase (SOD1) is an intriguing enzyme. It is one of the most important antioxidant defenses but can also present pro-oxidant activities, such as the bicarbonate-dependent peroxidase activity. On the other hand, the human enzyme (hSOD1) is a small protein (153 amino acids and 1 copper and 1 zinc ion per monomer), which in the native state is a remar…