CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Itália
Associate Professor (RDIDP) in the Department of Immunology at the Institute of Biomedical Sciences, University of São Paulo (ICB/USP) since 2013, and Habilitation in Immunogenetics at ICB/USP (2021). Earned a Bachelor's degree in Biological Sciences (1993-1999), a Ph.D. in Experimental and Clinical Pathology (2000-2003), and a Residency in Medical Genetics (2004-2008) from the University of Trieste (Italy), and completed a post-doctorate at the Children's Institute "Burlo Garofolo" in Trieste (Italy) (2003-2011). Visiting researcher at the Department of Genetics at the Federal University of Pernambuco (UFPE) and at the LIM-56 laboratory of the Faculty of Medicine at USP (FMUSP) (2011-2013). Holds a productivity research fellowship from CNPq, level 1D. Published 90 articles in the fields of human genetics, basic and clinical immunology (H-index = 31). Works in the areas of innate immunity and inflammation, focusing on the immunogenetics of the inflammasome; autoinflammatory diseases; inflammasome immunology; and medical and population genetics. (Source: Lattes Curriculum)
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Monogenic inflammasomopathies constitute a group of rheumatological disorders stemming from dysregulation of the inflammasome complex caused by gain-of-function mutations in inflammasome genes or molecules that indirectly affect its activation. The prototypes of this group of diseases are the Cryopyrin-Associated Periodic Syndrome (CAPS) and Familial Mediterranean Fever (FMF), associated …
Chronic kidney diseases are still a leading cause of death worldwide. Thus, the need for new treatment approaches is urgent. Here, we aim to unravel new sensing mechanisms for organelles on renal and immune cells and how the external and internal perception of unbalance is involved in responses which triggers injury, influences repair, and promotes renal tissue fibrosis. We hypothesize th…
Since the beginning of the COVID-19 pandemic, it has become clear that only a low percentage of individuals infected by the SARS-CoV-2 virus had a severe clinical picture with lung damage and/or extrapulmonary disease, which could lead to death. It clear suggests an individual predisposition partly constituted by the host genetic background.Taking into account that the activation of the i…
Inflammasome is a cytosolic complex responsible for the release of inflammatory cytokines IL-1ß and IL-18 in response to microbial and/or cellular stress stimuli. Although it plays a central role in the first line of defense and in the induction of inflammation and adaptive immunity, it may also be involved in chronic inflammation and tissue damage and thus contribute to most common disea…
Obesity is characterized by local and systemic chronic "sterile" inflammation in metabolically relevant organs and tissues.Recent findings suggest the multi-protein complex known as inflammasome plays a key role in regulating tissue inflammation during obesity and metabolic syndrome, as it is responsible for the secretion of inflammatory cytokines IL-1 B and IL-18. Recently, Hill and othe…
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Periodic Syndromes Associated with Cryopyrin (CAPS) are monogenic inflammasomopathies, meaning systemic autoinflammatory diseases caused by gain-of-function mutations in the NLRP3 gene. This gene encodes the NLRP3 inflammasome receptor, and its mutations lead to hyperactivation of the complex and increased production of inflammatory cytokines IL-1¿ and/or IL-18, as well as the induction o…
Hymenopterous stings such as bees, wasps, and some ants are known to cause allergic reactions to the venom injected into the skin in approximately 3% of the general population, which can lead to death from anaphylaxis. Although the type 1 hypersensitivity reaction (mediated by IgE) is recognized as the main response mechanism, the molecular mechanisms triggered by the injected venom and t…
The COVID 19 pandemic is caused by the emerging virus SARS-COV-2 and is responsible for more than 1 million deaths worldwide. The immunopathology of COVID-19 is characterized by a systemic inflammation with significant hematological changes such as neutrophilia and lymphopenia and an exacerbated production of inflammatory cytokines responsible for a viral sepsis in the most severe cases o…
The contribution of inflammasoma in human papillomavirus (HPV) infection and HPV-associated cervical carcinoma (HPV-CC) has not yet been fully elucidated. On the one hand, the production of inflammatory cytokines (IL-1², IL-18) in keratinocytes seems to be directly proportional to the progression of CC suggesting that HPV would activate the inflammassoma. However, there is also evidence t…
(Only some records are available in English at this moment)
Inflammasome activation exacerbates immune response to SARS-CoV-2 possibly contributing to SARS and thrombotic disease in COVID-19 patients. We recently reported that the NLRP3 inflammasome is dramatically activated in neutrophils isolated from severe COVID-19 patients. However up-to-now the exact mechanism of complex activation in SARS-CoV-2 infection remains unclear. COVID-19 patients …
| 2 / 2 | Ongoing grants |
| 7 / 5 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 7 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 19 / 16 | All research grants and scholarships |
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