Abstract
Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by a reciprocal chromosomal translocation between the long arms of chromosomes 9 and 22, which originates a short chromosome 22 known as the Philadelphia (Ph) chromosome. In this translocation t(9;22)(q34;q11), the union between two genes occurs, generating a leukemia-specific gene, the BCR-ABL; the chimeric pro…