Bachelor in Biomedical Sciences, Master and Ph.D. in Physiology, currently Full Professor of Physiology of the Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo. Main research interest centered in the cellular communication in the nervous system. (Source: Lattes Curriculum)
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The biological process of neurogenesis that consists of differentiation of neural stem cells (NSC) into neurons, occurs both in embryonic and adult phases. Therefore, NSC are being proposed as interesting tools for nervous system tissue regeneration and restoration of physiological conditions, as well as models for elucidation of pathophysiological development of neurological diseases. Pr…
Recent data of our laboratory indicate that the activation of TRPV1 channels induces apoptotic cell death during the development of the retina, which is partially dependent on nitrosative stress. Oxidative and endoplasmic reticulum stress may be also involved in these processes. Our preliminary data indicate that human retinoblastoma Y79 cells express TRPV1 channels, and that their activa…
The diagnosis of Alzheimer's disease (AD), a great public health problem, is imprecise and delayed (since the neurodegenerative processes begin years before the appearance of symptoms). The validation of AD biomarkers has the potential to afford early diagnosis and novel treatments. This project aims to investigate, in a multidisciplinary and translational fashion, the accumulation of b-a…
Stem cells (SC) are unspecialized cells withself renewal capacity and with the ability to originate different cell types | of the body. In recent years, SC nave emerged as a significant therapeutic promise for several diseases. Furthermore, cancer stem cells (CSC ) have been implicated in initiation and growth of tumors, resistance to conventional therapies and, consequently, in recurrenc…
(Only some records are available in English at this moment)
Parkinson's Disease (PD) is the second most common neurodegenerative disease in elderly, bringing a great socioeconomic impact due to the growing population aging scenario. It is mainly characterized by the death of dopaminergic neurons of the substantia nigra pars compacta and the consequent loss of dopamine in the striatum, besides that cell death may occur after an inflammatory conditi…
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder that affects the central nervous system, which can manifest itself genetically or sporadically. The main finding of this disorder is the death of dopamine producing neurons in the substantia nigra causing the characteristic symptoms of the disease; bradykinesia, rigidity, rest tremor and postural instability.…
The accelerated populational aging has as a result the increased incidence of diseases associated with aging, as well as the costs of medical treatments. Parkinson's disease (PD) is considered the second most common neurodegenerative disease in elderly people and is characterized by the presence of motor difficulties due to loss of dopaminergic neurons in the striatum. The loss of dopamin…
Parkinson's disease (PD) is the second most common neurodegenerative disease in the elderly. PD promotes motor disorders. Exercise, in turn, has been described in terms of its beneficial effects in PD with decreased neuronal loss, improvement of behavioral and changes in the pattern of cortical excitability. The objective of this project is to understand physical exercise as a possible wa…
(Only some records are available in English at this moment)
Parkinson's disease (PD) is considered the second most common neurodegenerative disease in elderly people and is characterized by the presence of motor difficulties, which is a consequence of neuronal degeneration in the substantia nigra pars compacta. A major neurotoxin used for PD study in animal models is 6-hydroxydopamine (6-OHDA), which exerts neurotoxic effects through the productio…
Parkinson's disease (PD) is the second most common neurodegenerative disease in the elderly. 20% of patients diagnosed with PD are discovered false-diagnosed after post mortem examination. Thus, it would be of great importance to develop techniques to accurately diagnose the disease in all stages in vivo. Positron emission tomography (PET) is a very effective diagnostic tool for noninvasi…
The Nox family of superoxide and hydrogen peroxide-producing proteins has emerged as an important source of reactive oxygen species in several neurodegenerative conditions. Seven Nox isoforms have been identified, namely Nox1, Nox2 (also known as gp91phox), Nox3, Nox4, Nox5, and Dual Oxidase 1 and 2 (Duox1 and Duox2), each one with their own specific regulatory subunities and mechanisms. …
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 23 / 8 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 52 / 9 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 81 / 23 | All research grants and scholarships |
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CV Lattes
ORCID