CV Lattes
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ORCID
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor in Biomedical Sciences, Master and Ph.D. in Physiology, currently Full Professor of Physiology of the Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo. Main research interest centered in the cellular communication in the nervous system. (Source: Lattes Curriculum)
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The incidence of several diseases increases with aging, due to several changes that include genetic, epigenetic, organic and systemic factors, among others. This picture is very evident in the nervous system, a target of several pathological processes linked to aging. In the present proposal, we aim to study several aspects related mainly to the two most prevalent neurodegenerative diseas…
This proposal discusses the global increase in the prevalence of dementia, with a specific focus on Alzheimer's Disease (AD) due to the aging population and the urgent need to develop preventative strategies and effective treatments. It is estimated that there are around 50 million cases of dementia, with expectations of a significant rise by the year 2050. AD, as the leading cause of dem…
Parkinson´s disease (PD) represents a major public health issue, since it is the second most prevalent neurodegenerative disease, behind Alzheimer´s disease. The number of cases of PD in Brazil is estimated to reach more than 600,000 in the next 5-8 years. Despite intense research on the physiopathological basis of PD, the mechanisms that trigger the disease are incompletely understood. T…
The biological process of neurogenesis that consists of differentiation of neural stem cells (NSC) into neurons, occurs both in embryonic and adult phases. Therefore, NSC are being proposed as interesting tools for nervous system tissue regeneration and restoration of physiological conditions, as well as models for elucidation of pathophysiological development of neurological diseases. Pr…
Recent data of our laboratory indicate that the activation of TRPV1 channels induces apoptotic cell death during the development of the retina, which is partially dependent on nitrosative stress. Oxidative and endoplasmic reticulum stress may be also involved in these processes. Our preliminary data indicate that human retinoblastoma Y79 cells express TRPV1 channels, and that their activa…
(Only some records are available in English at this moment)
Alzheimer's Disease (AD) is the most prevalent form of dementia. It is a progressive neurodegenerative disorder associated with aging in its sporadic form, primarily affecting women. AD is characterized by the presence of ¿-amyloid plaques (¿A) and intracellular neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau, which are associated with neuronal death and inflammatory pr…
This proposal discusses the global increase in the prevalence of dementia, with a specific focus on Alzheimer's Disease (AD) due to the aging population and the urgent need to develop preventative strategies and effective treatments. It is estimated that there are around 50 million cases of dementia, with expectations of a significant rise by the year 2050. AD, as the leading cause of dem…
Down Syndrome (DS) is a genetic condition resulting from the triplication of chromosome 21in humans, responsible for causing multiple health problems. The syndrome influences thedevelopment of the nervous system, and many of the problems development areophthalmological, mainly affecting the retina-thalamus-cortex pathway, demonstrating athickening of the cortical region of the brain of pa…
(Only some records are available in English at this moment)
Alzheimer's disease (AD) is a neurodegenerative disease that represents the most common cause of dementia. The hallmarks used to diagnose AD are the formation of neuritic plaques and neurofibrillary tangles, associated with neuroinflammation. Manifestation rates of this disease have increased in recent years, which makes it essential to do an in-depth study and define the risk factors for…
Alzheimer's disease (AD) is pathologically characterized by the deposition of beta-amyloid (¿A) protein plaques and neurofibrillary tangles (NFTs), in addition to an important involvement of neuroinflammation, leading to neuronal loss and functional consequences, as well as cognitive and behavioral changes. Recent research using phenotypic screening based on lipopolysaccharide (LPS)-induc…
Parkinson's Disease (PD) is a neurodegenerative condition that is characterized by the death of dopaminergic neurons of the substantia nigra pars compacta of the brain, and that includes motor as well as non-motor symptoms. An important aspect of this pathology is a marked neuroinflammation, which causes a neurotoxic deleterious cycle, which promotes the death of even more cells in the ce…
(Only some records are available in English at this moment)
Neuroinflammation is an inflammatory response in the central nervous system triggered by various factors such as infections, trauma, toxins, or neurodegenerative diseases like Parkinson's Disease (PD). While it plays a beneficial role in tissue repair and pathogen removal, excessive or chronic neuroinflammation can lead to neurotoxic factor release, tissue damage, and neurodegeneration. M…
Parkinson's disease (PD) is a devastating disease clinically diagnosed by motor dysfunctions that affect millions of people worldwide. Among the neuropathological hallmarks are the degeneration of dopaminergic neurons in the substantia nigra pars compacta and the loss of dopamine in its projection area, the striatum. Currently there is no cure for PD, so many researchers aim to develop ne…
Parkinson's disease (PD) is considered the second most common neurodegenerative disease in elderly people and is characterized by the presence of motor difficulties, which is a consequence of neuronal degeneration in the substantia nigra pars compacta. A major neurotoxin used for PD study in animal models is 6-hydroxydopamine (6-OHDA), which exerts neurotoxic effects through the productio…
Parkinson's disease (PD) is the second most common neurodegenerative disease in the elderly. 20% of patients diagnosed with PD are discovered false-diagnosed after post mortem examination. Thus, it would be of great importance to develop techniques to accurately diagnose the disease in all stages in vivo. Positron emission tomography (PET) is a very effective diagnostic tool for noninvasi…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 25 / 10 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 57 / 14 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 94 / 36 | All research grants and scholarships |
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