graduation at Farmácia Bioquímica from Universidade Estadual Paulista Júlio de Mesquita Filho (1979), master's at Physiology from Universidade de São Paulo (1984) and doctorate at Physiology from Universidade de São Paulo (1988). Has experience in Physiology, focusing on Physiology of Organs ans Systems, acting on the following subjects: ingestao de agua, pressao arterial, angiotensina ii, ingestao de sodio and carbacol. (Source: Lattes Curriculum)
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Obesity and hypertension are the leading cause of death in the world. Obesity and overweight contribute to elevated blood pressure in many patients with essential hypertension. Experimental and clinical studies indicate that visceral obesity induces hypertension by increasing renal sodium reabsorption through multiple mechanisms including activation of the sympathetic nervous system (SNS)…
The objective of the Project is to elucidate neural mechanisms that process autonomic information associated with compensatory cardiovascular, respiratory and behavioral (thirst and sodium appetite) adjustments to dehydration and underlying arterial hypertension. The study will focus on a model circuit involving a triangle formed by nucleus of the solitary tract (NTS), rostro-ventrolatera…
Important inhibitory mechanisms for the control of sodium and water intake are present in the lateral parabrachial nucleus (LPBN). Serotonergic, cholecystokinergic and glutamatergic mechanisms and the corticotropin releasing hormone (CRF) in the LPBN inhibit water and sodium intake, whereas gabaergic, opioid and alpha2 adrenergic mechanisms in the LPBN have opposite effects. Besides the c…
(Only some records are available in English at this moment)
The study of sialagogue substances is of clinical interest because of their use in patients with xerostomia. Among them cholinergic agonists are particularly important and in this pharmacological class pilocarpine is one of the most important. Pilocarpine injected peripherally induces salivation, water intake and pressor response. The intracerebroventricular (icv) injection of muscarinic …
Obesity and hypertension are the leading cause of death in the world. Obesity and overweight contribute to elevated blood pressure in many patients with essential hypertension. Experimental and clinical studies indicate that visceral obesity induces hypertension by increasing renal sodium reabsorption through multiple mechanisms including activation of the Sympathetic Nervous System (SNS)…
The study of sialagogue substances is of clinical interest because of their usefulness in patients with xerostomia. Cholinergic agonists stand out, pilocarpine being one of the most important. It induces salivation, injected peripherally and also water intake. The intracerebroventricular injection (icv) of muscarinic antagonists showed that the salivation produced by pilocarpine injected …
(Only some records are available in English at this moment)
Renovascular hypertension affects 1 - 4% of the hypertensive population and it is the largest cause of secondary hypertension, affecting 25% to 35% of the patients with secondary hypertension (Tafur-Soto e White, 2015). Renovascular hypertension is induced experimentally by unilateral stenosis of a renal artery, which decreases renal perfusion pressure leading to renin release and also, a…
Recent studies showed that activation of alpha2-adrenoceptors with bilateral LPBN injections of moxonidine (alpha2-adrenoceptor/imidazoline receptor agonist) or noradrenaline strongly enhances 0.3 M NaCl intake induced by subcutaneous treatment with the diuretic furosemide (FURO) when combined with a low dose of the antihypertensive drug, captopril. However, noradrenaline injected into LP…
| 17 / 9 | Completed research grants |
| 39 / 9 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 59 / 20 | All research grants and scholarships |
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