CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Faculdade de Ciências Agrárias e Veterinárias (FCAV) (Institutional affiliation from the last research proposal) Birthplace: Brazil
has a Bachelor of Science degree in Biology from State University of Campinas (2003), a Master of Science degree in Genetics and Molecular Biology from State University of Campinas (2006), a Doctor of Philosophy degree in Genetics from Michigan State University (2011), Post-Doctorate experience in Biochemistry and Molecular Biology from Tampere University, Finland (2013), and Livre-Docência in Biotechnology from the Sao Paulo State University (2024). He has experience in Molecular Biology, Genetics and Biochemistry/Metabolism, specifically in topics related to Mitochondrial Biology, such as: 1) the Use of Alternative Enzimas for the Functional Understanding of the Mitochondrial Respiratory Chain and to Combat Mitochondrial Disorders; and 2) Mitochondrial Genome Structure and Maintenance Mechanisms. He uses and advocate for the use of Drosophila melanogaster as one of the most important model organisms in life sciences research, due to its low culture costs and to the versatility of the molecular genetics tools available. He was a faculty member of the Department of Biotechnology, College of Agricultural and Veterinary Sciences of Jaboticabal, Sao Paulo State University (2013-2025), and currently is with the Department of Biochemistry and Immunology of the Ribeirão Preto Medical School, University of Sao Paulo. (Source: Lattes Curriculum)
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Although the mitochondrial alternative oxidase (AOX) is naturally absent in vertebrates and insects, its xenotopic expression in Drosophila and mammalian models has been shown to combat mitochondrial and related dysfunctions, with potential for its deployment as a human therapy enzyme in the future. AOX is a non-proton pumping, mitochondrial inner membrane enzyme that can bypass respirato…
Although the mitochondrial alternative oxidase (AOX) is naturally absent in vertebrates and insects, its xenotopic expression in Drosophila and mammalian models has been shown to combat mitochondrial and related dysfunctions, with potential for its deployment as a human therapy enzyme in the future. AOX is a non-proton pumping, mitochondrial inner membrane enzyme that can bypass respirato…
Although the mitochondrial alternative oxidase (AOX) is naturally absent in vertebrates and insects, its xenotopic expression in Drosophila and mammalian models has been shown to combat mitochondrial and related dysfunctions, with potential for its deployment as a human therapy enzyme in the future. AOX is a non-proton pumping, mitochondrial inner membrane enzyme that can bypass respirato…
Mitochondria are essential organelles in eukaryotic cells as they are involved in central pathways including energy metabolism and intracellular signaling. Besides being the main cellular site for ATP generation, they are involved in redox signaling, intracellular calcium homeostasis and cell fate after stress. Moreover, they contain their own independent genome. In humans, the mitochondr…
The respiratory chain alternative enzymes constitute additional pathways to the mitochondrial oxidative phosphorylation (OXPHOS) system, in which oxygen consumption is uncoupled from ATP production. The expression of alternative oxidases and alternative NADH dehydrogenases from tunicates and fungi in the fruit fly Drosophila melanogaster, in the mouse and in cultured human cells has prove…
Drosophila melanogaster has been widely used as a model organism in the study of various human diseases, because of the homology of its genes with human genes, its short life cycle, the possibility of studying all stages of development (larval, pupal, and adult), and its low maintenance cost. Thus, studies with Drosophila melanogaster and the alternative oxidase (AOX) enzyme, a component …
In this project, we will investigate how alternative oxidase (AOX) influences mitochondrial metabolism, particularly under alterations in lactate dehydrogenase (LDH) levels, exploring its effects on cellular respiration, redox metabolism, and growth in Drosophila. To achieve this, we will perform high-resolution respirometry assays to assess oxygen consumption, ATP production, and ROS lev…
(Only some records are available in English at this moment)
Drosophila melanogaster is undoubtedly one of the most useful model organisms in the life sciences. This fly species was initially used to consolidate the principles of heredity and to establish the basic concepts of populations genetics and the synthetic theory of evolution, but it can now offer scientists much more: the possibility of investigating a multitude of cellular and biological…
Drosophila melanogaster is undoubtedly one of the most useful model organisms in the life sciences. This fly species was initially used to consolidate the principles of heredity and to establish the basic concepts of populations genetics and the synthetic theory of evolution, but it can now offer scientists much more: the possibility of investigating a multitude of cellular and biological…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing grants |
| 2 / 2 | Completed research grants |
| 7 / 7 | Ongoing scholarships in Brazil |
| 25 / 22 | Completed scholarships in Brazil |
| 37 / 34 | All research grants and scholarships |
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