CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor's in Pharmacy from Universidade de São Paulo (1997), master's in Pharmaceutical Sciences from Universidade Estadual Paulista Júlio de Mesquita Filho (2000) and PhD in Pharmaceutical Sciences from Faculdade de Ciências Farmacêuticas de Ribeirão Preto/USP (2005). She was Assistant Professor at Albany College of Pharmacy and Health Sciences from 2008 to 2013. She is currently Associate Professor at the Institute of Biomedical Sciences at University of Sao Paulo. Her scientific interests are focused on nanomedicine and drug delivery. (Source: Lattes Curriculum)
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Considering the high incidence of breast tumors and the lack of strategies for local management of non-invasive cases, as well as effective, safe and well-accepted chemoprevention alternatives for high-risk population, we propose the development of nanotechnology-based strategies to fill this gap. To increase treatment efficacy, we propose to co-encapsulate combinations of cytotoxic, cicl…
Considering the high incidence of breast tumors and the lack of strategies for local management of non-invasive cases, as well as effective, safe and well-accepted chemoprevention alternatives for high-risk population, we propose the development of nanotechnology-based strategies to fill this gap. To increase treatment efficacy, we propose to co-encapsulate combinations of cytotoxic, cicl…
Considering the high incidence of skin and breast tumors and the unavailability of strategies to localize drugs in these tissues while avoiding systemic exposure and side effects, we propose the development of cationic nanocarriers for topical delivery of chemopreventive and chemotherapeutic agents. Because tumor development and progression are multifactorial, the co-incorporation of comp…
Colorectal cancer (CRC) is a serious global health issue, with 1.9 million new cases and over 900,000 deaths in 2022, accounting for 9.3% of all cancer-related deaths. There is also a concerning rise in incidence among younger populations. Conventional treatment involves surgical removal of the tumor, often combined with chemotherapy, with 5- fluorouracil (5-FU) being the primary drug use…
Psoriasis is a chronic inflammatory skin disease that presents diverse clinical manifestations and significantly impacts the quality of life of patients. Current treatments, particularly the first-line treatment with topical corticosteroids, often cause several adverse effects both locally and systemically, highlighting the need for effective and safe novel strategies for the long-term ma…
This project aims at developing and evaluating functionalized vesicular nanocarriers for the intraductal administration of a combination of cytotoxic drugs for treatment of localized forms of breast cancer, integrating greater selectivity and efficacy. It is justified by the gaps in the current breast cancer management strategies, including treatment of the non-invasive forms, such as int…
(Only some records are available in English at this moment)
Breast cancer represents the most incident type of cancer worldwide among women with a high mortality rate, with around 2.3 million cases and more than 685.000 deaths reported in 2020. This scenario emphasizes the importance of new studies to enhance our understanding of the carcinogenesis processes and the treatment for this type of cancer. Considering the low selectivity and occurrence …
Cancer is the term used to describe a heterogeneous group of diseases, characterised by the proliferation of cells that can invade tissues and organs. Within this group is breast cancer, the cancer that most affects women worldwide. Despite that, the conventional methods of diagnosis and treatment available today are scarce and still very limited in combating the disease, which results in…
The increase in the incidence of difficult-to-heal injuries due to population aging and the prevalence of certain types of chronic diseases (such as diabetes) requires a constant search for new treatment strategies that combine lower cost and good efficacy. Since disturbances in revascularization and the occurrence of microbial infections contribute to healing difficulties, we propose in …
(Only some records are available in English at this moment)
In this project, we propose to develop and evaluate an in situ-forming multifunctional hydrogel for intramammary delivery of fenretinide and a mitogen-activated protein kinase-activated protein kinase-2 inhibitor peptide (YARA) aiming at breast cancer chemoprevention. Due to the low aqueous solubility of fenretinide, we envisioned hydrogels enriched with fenretinide-loaded nanostructured …
The development of novel nanotechnology-based therapies should comprise not only the complete characterization of the nanoparticles' physicochemical properties but also in vitro and in vivo activity and toxicity evaluation. Considering the well-documented toxicity of antitumor drug candidate chromomycin, studying whether nanoencapsulation modulates its toxic effects is essential. However,…
The skin, being the largest organ of the body, plays a critical role in protecting against external insults and regulating various physiological processes such as temperature maintenance and sensory perception. Comprising the epidermis and dermis, it orchestrates a complex interplay of cellular interactions to ensure its integrity and overall health. However, chronic wounds, such as diabe…
Acute lymphoblastic leukemia (ALL) represents 1 every 4 pediatric cancer and commonly affects lymphocyte B cells. The survival rate increased to almost 70% after the approval of Chimeric Antigen Receptor (CAR) T cell therapy, however the limitations for a wide-scale production, costs and severe adverse effects hinders its application. In this project, we propose the optimization and appli…
Breast cancer have a high incidence worldwide, but there is a lack of effective and well-accepted alternatives for localized treatment of noninvasive forms of the disease, such as ductal carcinoma in situ (DCIS). In this project, we propose the development of nanocarriers for intraductal drug administration, aiming to optimize the drug localization in the breast tissue, improving efficacy…
Despite the high incidence of breast cancer, there are few chemoprevention strategies available to the high-risk population. Since drug presence only in the mammary tissue is required for chemoprevention, local drug application to the breasts via local-transdermal therapy (LTT) or intradermal administration can offer efficacy, less systemic adverse effects and improved compliance compared…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 1 / 1 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 22 / 20 | Completed scholarships in Brazil |
| 3 / 3 | Ongoing scholarships abroad |
| 4 / 4 | Completed scholarships abroad |
| 38 / 36 | All research grants and scholarships |
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