CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Dr Ximenez had his PhD in Toxicology at School of Pharmaceutical Sciences of Ribeirão Preto from University of São Paulo, Brazil. During his doctoral studies, he was trained in a wide variety of lab techniques that were applied to clinical science projects aimed at identifying the determinants of pharmacological response and variability in humans. He has experience in mass spectrometry (sample preparation, analytical method development and validation, HPLC and LC-MS/MS), molecular biology (i.g. nucleic acid extraction, RFLP-PCR and qPCR) and some experience on R language (ggplot2, tidyverse, carrot, plyr and Bioconductor). Dr Ximenez is interested in the interplay of epigenetic, genetics and the environment, namely how genetic variants and environmental variables can affect variation in phenotypes. The ultimate goal is to translate his findings into new strategies for prevention and treatment. ResearcherID: http://www.researcherid.com/rid/G-7863-2012. (Source: Lattes Curriculum)
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A total of 1.3 million people died from tuberculosis (TB) in 2022 (including 167,000 people with HIV). Worldwide, TB is the second leading infectious killer after COVID-19 (above HIV and AIDS). Rifampicin (RIF) is an essential component among the four first-line anti-tuberculosis drugs (FLATDs), being the other three: isoniazid (INH), pyrazinamide (PZA), and ethambutol (ETH). For antibiot…
A total of 1.3 million people died from tuberculosis (TB) in 2022 (including 167,000 people with HIV). Worldwide, TB is the second leading infectious killer after COVID-19 (above HIV and AIDS). Rifampicin (RIF) is an essential component among the four first-line anti-tuberculosis drugs (FLATDs), being the other three: isoniazid (INH), pyrazinamide (PZA), and ethambutol (ETH). For antibiot…
The organic anion transporters (OAT) 1 and 3 are of fundamental importance in renal excretion and consequently in the dosage regimen of drugs. However, little is known about the influence of inflammation associated with kidney infection, especially in pregnant women, on the expression/activity of these transporters. In order to understand the impact of inflammation caused by urinary tract…
Neurocryptococcosis is a subacute meningoencephalitis caused by the fungus Cryptococcus spp., occurring most commonly in patients diagnosed with HIV or other forms of immunosuppression. Amphotericin B (AnfB), the drug of choice for the treatment of neurocryptococcosis, has low permeability in the blood-brain barrier (BBB), with consequent low concentrations in the cerebrospinal fluid (CSF…
Neurocryptococcosis is a subacute meningoencephalitis caused by the fungus Cryptococcus spp., occurring more commonly in patients infected with HIV or with other forms of immunosuppression. Amphotericin B (AnfB), the drug of choice for the treatment of neurocryptococcosis, has low permeability in the blood-brain barrier (BBB), with consequent low concentrations in the cerebrospinal fluid …
Since the human genome was sequenced, extensive effort has been placed into mapping the role of genes in the onset of disease. It was expected that the scientific community would be able to explain the cause of disease and understand the genetic basis of health. However, it has found that while the genetic contribution to individual conditions varies, non-genetic factors have far more sig…
The study hypothesis is to investigate the influence of age and hormonal status on tamoxifen kinetic and metabolism in breast cancer patients. Thus, two groups of patients will be defined according to age and hormonal status, a pre-menopausal group (age < 50 years) and another postmenopausal (age > 60 years). Blood samples will be collated from patients within 24 hours after tamoxifen dai…
The main goal of this research proposal is to determine the dose and dosing regimen required to ensure comparable pharmacological response to TB treatment in paediatric patients with pulmonary TB and EPTB, both DS-TB and DR-TB. For this we propose, on the one hand, the use of the modelling and simulation (M&S) in silico strategies to obtain population pharmacokinetics (PK) models. And the…
The study aims to investigate the influence of age, hormonal status, CYP2D6, CYP3A and P-gp in vivo activities and genetic polimorphisms on tamoxifen kinetic disposition and metabolism in breast cancer patients. Thus, two groups of patients were defined according to age and hormonal status, pre-menopausal group (age < 50 years) and postmenopausal group (age > 60 years). Blood samples were…
| 2 / 2 | Ongoing grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 3 / 3 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 9 / 9 | All research grants and scholarships |
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