Abstract
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects motor neurons. 5 to 10% of the total cases of ALS are familial and the remainder, sporadic. The human gene VAPB encodes the VAPB protein, which is located in the endoplasmic reticulum (ER) membrane and is probably involved in diverse cellular functions, including neurotransmission. This protein is associated t…