graduate at Biologia from Universidade Estadual de Campinas (1989), master's at Genetics from Universidade Estadual de Campinas (1992) and ph.d. at Genetics from Universidade Estadual de Campinas (1997). Has experience in Microbiology, acting on the following subjects: pathogenicity, salmonella enterica, genomics and bacterial resistance. (Source: Lattes Curriculum)
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Salmonella enterica is an important animal and human pathogen and its control is essential in the public health. Monitoring the appearance and characteristics of highly pathogenic and more invasive strains is one of the important aspects of this control. In addition, using molecular biology techniques, S. enterica can be attenuated and modified to carry heterologous molecules, with applic…
Previous results from our group indicated that null-mutants of Salmonella enterica for genes encoding Naps (Nucleoid-associated proteins) are attenuated and able to induce protection in the murine model. Data also indicated that some strains presented antitumor properties. Altogether, those results indicate an important biological role of NAPs in S. enterica. Therefore, the general object…
Recent results from our group indicated that mutants of Salmonella enterica for genes encoding NAPs (nucleoid-associated proteins) are virulence attenuated and able to induce, in different extension, protection in the mouse model of infection. These results suggest an important role of NAPs in bacterial virulence. Based on this, the aim of this project is further study the role of differe…
Preliminar results of our group indicated inhibition activity of violacein to Staphylococcus aureus (including Methicillin resistant-MRSA strains), an important bacterial pathogen to humans and other annimals. Continuing these analyses, the ain of this project is to evaluate the biological activity of violacein to S. aureus exhibiting intermediate vancomycin resistance (VISA and hetero-VI…
(Only some records are available in English at this moment)
Gram negative bacteria has a complex morphology, composed of a plasma membrane and a cell wall, that are composed of a thin layer of peptidoglycan and a lipopolysaccharide outer membrane, which makes them relatively more resistant to drugs and bactercidal agents. In such context, with the increase in the use of antibiotics, bacteria have developed multidrug resistance. The multidrug resis…
Gram-negative bacteria such as Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp., Salmonella and Helicobacter pylori are multiresistant bacteria of clinical interest. Recombinant phage endolysins therefore appear as potential new antimicrobials to combat infections caused by antibiotic-resistant Gram-negative bacteria. Endolysins target the peptidog…
Salmonella is a gram-negative bacilli, facultative anaerobic and the Salmonella enterica Typhimurium (S. typhimurium) is the most common and studied serovar that infect humans. This bacterium can be easily genetically manipulated and has an available genome sequence. That makes it possible to use these mutants for different goals, like vaccines and tumor-treatment, considering recent stud…
(Only some records are available in English at this moment)
Despite efforts to reduce the levels of pathogens in foods, they persist, causing serious problems in human health and an impacting the economy. The overuse of antibiotics has contributed to the increase of this issue, leading to the emergence of antibiotic-resistant pathogenic bacteria. The wide distribution of Salmonella spp. between animals and its maintenance in food contribute to thi…
Optical molecular imaging (OMI) is a technique developed in molecular imaging based on genomics, proteomics, and modern optical imaging technique, through qualitative or quantitative observation and investigates the activities of molecules and cells in physiological and pathological processes in vivo and in vitro with the use of specific molecular markers. Recently, imaging techniques in …
Recent data from our research group showed that null mutant strains of Salmonella enterica to genes encoding Naps (nucleoid-associated proteins) were attenuated for virulence and capable of inducing, in variable degrees, protection in the murine infection model. These results suggested an important role of different Naps in the bacterial virulence. During the development of our Postdoc pr…
| 2 / 2 | Ongoing research grants |
| 13 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 32 / 17 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 51 / 28 | All research grants and scholarships |
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CV Lattes
ORCID