Abstract
Although sickle cell anemia (SCA) resulting from homozygosity for a single mutation at position 6 of the ²-hemoglobin locus, phenotypically this disease is very heterogeneous, so that different patients may have significantly different clinical outcomes. The compound heterozygous with other hemoglobin variants also modulates the polymerization of HbS, and the hemoglobin C (HbC) structural…