CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Medicina from Faculdade de Medicina de Ribeirão Preto- USP (1984), master's at Endocrinology from Faculdade de Medicina de Ribeirão Preto - USP (1991) and doctorate at Medicina from Faculdade de Medicina de Ribeirão Preto - USP (1995). Has experience in Medicine, focusing on Endocrinology, acting on the following subjects: acth, cortisol, anp, mutação and crh. (Source: Lattes Curriculum)
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IntroductionFructose a major constituent of modern diet with same chemical formula as glucose was initially thought to be beneficial to diabetics due to its low glycemic index and its lesser suppression of food intake (Luc and Kim-anne, 2010). But its metabolism is different from that of glucose due to its complete hepatic extraction and rapid hepatic conversion into glucose, glycogen, la…
The endocrine and nervous systems interact reciprocally with peripheral organ and tissues in the regulation of several body functions. Homeostatic responses are activated by peripheral signals, such as metabolic factors, glucose, FFA, electrolytes, hormones, cytokines, and myokines that interact with neuronal and non-neuronal circuitries for the maintenance of internal milieu. Besides its…
October, 1st, 2020 Opening session - 50 years of the Graduate Program in Physiology: looking into the future and Module 1- Prenatal and neonatal programming and its impact on adult life; October, 9th, 2020 Module 2- Contemporary Cardiovascular Physiology; October, 15th, 2020 Module 3- Translational Physiology and Module 4 -Aging; October, 22nd, 2020 Module 5 - Understanding biological co…
The proposed project will bring together investidators from the University of São Paulo (USP), the University of Campinas (UNICAMP) an the University of Michigan Health System (UMHS) with related scientific interest. The investigators from UMHS are funded by de NIH and the investigators from USP and UNICAMP are funded by FAPESP. A two-years planning grant is proposed to build upon methods…
The leptin, an adipocyte-derived hormone, and estradiol , , play an important role in the control of energy homeostasis. Through their actions in the central nervous system (CNS), more specifically in the hypothalamus, leptin promotes a state of negative energy balance (decreased food intake and increased energy expenditure). Many of these actions of leptin are mediated by the activation …
(Only some records are available in English at this moment)
The prevalence of global obesity has increased significantly in recent decades at different age. Obesity is characterized by the presence of excess body adiposity and comprises a risk factor for coronary disease and metabolic syndrome. Nutritional changes that occur during developmental period can affect energy homeostasis in adult life. Prenatal and neonatal programming has been relat…
Energy homeostasis involves a complex integration of multiple signals about the body's energy demand. Several hypothalamic regions, such as the paraventricular nucleus (PVN), arcuate nucleus (ARC), ventromedial nucleus (VMH), dorsomedial nucleus (DMH), and lateral hypothalamic area (LHA), are involved in the neural circuit that regulates food intake and are responsible for integrating the…
Obesity is associated with white adipose tissue hypertrophy and the increase of systemic inflammatory markers, which contributes to metabolic disorders. In this context, a phosphodiesterase 4 enzyme inhibitor has shown promise in reducing obesity's effects. Zhang et al. (2009), showed that mice fed a high-fat diet had reduced adiposity, lower serum leptin levels, as well as lower levels o…
Obesity became a public health issue as it is characterized by chronic systemic inflammation, affecting regions such as the hypothalamus and causing the development of other health complications, such as cardiovascular diseases, insulin and leptin resistance. Therefore, there is a clear interest in studying the mechanisms that are activated on inflammation and how to attenuate these effec…
(Only some records are available in English at this moment)
According to the World Health Organization the obesity become a global epidemic and the number of obese individuals continues to grow. Therefore understanding the complex neurocircuitry regulating food intake and energy expenditure becomes more pivotal to determining effective treatments and therapies against obesity. The hypothalamic-pituitary-thyroid (HPT) axis, composed by thyrotropin-…
During the endotoxemia acutely induced by the lipopolysaccharide (LPS) (100micrograms/kg), we observed hypophagia and reduced body weight gain, in addition to the increased production of inflammatory cytokines. These responses are associated with increased plasma leptin levels. However, animals treated with repeated doses of LPS did not show hypophagia and reduced body weight gain, indica…
| 2 / 2 | Ongoing grants |
| 10 / 8 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 26 / 14 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 44 / 29 | All research grants and scholarships |
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