Lucila Leico Kagohara Elias

• Abstract

  The proposed project will bring together investidators from the University of São Paulo (USP), the University of Campinas (UNICAMP) an the University of Michigan Health System (UMHS) with related scientific interest. The investigators from UMHS are funded by de NIH and the investigators from USP and UNICAMP are funded by FAPESP. A two-years planning grant is proposed to build upon metho...

  Development of mouse models using CRISPR-Cas9 technology, AP.R SPRINT

• Abstract

  The leptin, an adipocyte-derived hormone, and estradiol , , play an important role in the control of energy homeostasis. Through their actions in the central nervous system (CNS), more specifically in the hypothalamus, leptin promotes a state of negative energy balance (decreased food intake and increased energy expenditure). Many of these actions of leptin are mediated by the activatio...

  Role of STAT3 and ERK in SF1 neurons of hypothalamus in the effects of leptin and estradiol on energy homeostasis, AP.R

• Abstract

  The hypothalamus is essential for the maintainance of extracellular volume and tonicity, as well as energy homeostasis. In this study we aim to clarify the involvement of neuronal and glial components in the integrative responses, as well as the participation of key neurotransmitters, neuromodulators, hormones and neuropeptides in the neuroendocrine control of both water and sodium inta...

  Energy balance and body fluid homeostasis control: from cells to the physiological systems, AP.TEM

(Only some records are available in English at this moment)

• Abstract

  It is well known that obesity is related to chronic low-grade inflammation and an increase in pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF). The inhibition of Phosphodiesterase 4 (PDE4) can strongly inhibit the release of TNF and reduce inflammation after LPS challenge. Additionally, it was shown that PDE4 -/- mouse is resistant to diet-induced obesity. This study...

  The role of PDE4 inhibition on hypothalamic neuroinflammation and leptin resistance, BP.IC

• Abstract

  There is an increasing in the prevalence rate of obesity in the world. The prevalence of obesity-related chronic diseases, such as diabetes and ischemic heart disease is also increasing. Several evidence points out to the association of development of obesity, metabolic syndrome and chronic diseases and the nutritional conditions during the pre- and neonatal period, suggesting the exist...

  The role of astrocytes on neonatal nutritional programming in mice, BP.IC

• Abstract

  Energy homeostasis is regulated by hypothalamic neurons sensitive to circulating factors such as hormones and nutrients. Among the hormones, estradiol influences energy homeostasis, metabolism in adipocytes and energy expenditure. In addition, estradiol plays a key role in bone remodeling, reducing osteoclastogenesis. Bone remodeling involves the RANK/RANKL/OPG system, whose activity is...

  The role of osteoprotegerin on the estradiol effects in energy homeostasis, BP.IC

(Only some records are available in English at this moment)

• Abstract

  According to the World Health Organization the obesity become a global epidemic and the number of obese individuals continues to grow. Therefore understanding the complex neurocircuitry regulating food intake and energy expenditure becomes more pivotal to determining effective treatments and therapies against obesity. The hypothalamic-pituitary-thyroid (HPT) axis, composed by thyrotropi...

  Role of hypothalamic AgRP/NPY neurons in the Hypothalamus-Pituitary-Thyroid axis control in fed and fasted mice, BE.EP.PD

• Abstract

  During the endotoxemia acutely induced by the lipopolysaccharide (LPS) (100micrograms/kg), we observed hypophagia and reduced body weight gain, in addition to the increased production of inflammatory cytokines. These responses are associated with increased plasma leptin levels. However, animals treated with repeated doses of LPS did not show hypophagia and reduced body weight gain, indi...

  Role of PI3K signaling pathway in endotoxin-induced leptin resistance, BE.EP.PD