CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
bachelor's at Medicina from Faculdade de Medicina de Ribeirão Preto- USP (1984), master's at Endocrinology from Faculdade de Medicina de Ribeirão Preto - USP (1991) and doctorate at Medicina from Faculdade de Medicina de Ribeirão Preto - USP (1995). Has experience in Medicine, focusing on Endocrinology, acting on the following subjects: acth, cortisol, anp, mutação and crh. (Source: Lattes Curriculum)
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The endocrine and nervous systems interact reciprocally with peripheral organ and tissues in the regulation of several body functions. Homeostatic responses are activated by peripheral signals, such as metabolic factors, glucose, FFA, electrolytes, hormones, cytokines, and myokines that interact with neuronal and non-neuronal circuitries for the maintenance of internal milieu. Besides its…
October, 1st, 2020 Opening session - 50 years of the Graduate Program in Physiology: looking into the future and Module 1- Prenatal and neonatal programming and its impact on adult life; October, 9th, 2020 Module 2- Contemporary Cardiovascular Physiology; October, 15th, 2020 Module 3- Translational Physiology and Module 4 -Aging; October, 22nd, 2020 Module 5 - Understanding biological co…
The proposed project will bring together investidators from the University of São Paulo (USP), the University of Campinas (UNICAMP) an the University of Michigan Health System (UMHS) with related scientific interest. The investigators from UMHS are funded by de NIH and the investigators from USP and UNICAMP are funded by FAPESP. A two-years planning grant is proposed to build upon methods…
The leptin, an adipocyte-derived hormone, and estradiol , , play an important role in the control of energy homeostasis. Through their actions in the central nervous system (CNS), more specifically in the hypothalamus, leptin promotes a state of negative energy balance (decreased food intake and increased energy expenditure). Many of these actions of leptin are mediated by the activation …
(Only some records are available in English at this moment)
Obesity occurs due to an imbalance between food intake and caloric expenditure and affects millions of people around the world, being linked to an increased risk for heart disease, Diabetes Mellitus and metabolic syndrome. Women at the end of their reproductive life (menopause) are at higher risk of developing Obesity when compared to men. Several studies have shown that this event occurs…
It is well known that obesity is related to chronic low-grade inflammation and an increase in pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF). The inhibition of Phosphodiesterase 4 (PDE4) can strongly inhibit the release of TNF and reduce inflammation after LPS challenge. Additionally, it was shown that PDE4 -/- mouse is resistant to diet-induced obesity. This study a…
There is an increasing in the prevalence rate of obesity in the world. The prevalence of obesity-related chronic diseases, such as diabetes and ischemic heart disease is also increasing. Several evidence points out to the association of development of obesity, metabolic syndrome and chronic diseases and the nutritional conditions during the pre- and neonatal period, suggesting the existen…
Energy homeostasis is regulated by hypothalamic neurons sensitive to circulating factors such as hormones and nutrients. Among the hormones, estradiol influences energy homeostasis, metabolism in adipocytes and energy expenditure. In addition, estradiol plays a key role in bone remodeling, reducing osteoclastogenesis. Bone remodeling involves the RANK/RANKL/OPG system, whose activity is i…
(Only some records are available in English at this moment)
According to the World Health Organization the obesity become a global epidemic and the number of obese individuals continues to grow. Therefore understanding the complex neurocircuitry regulating food intake and energy expenditure becomes more pivotal to determining effective treatments and therapies against obesity. The hypothalamic-pituitary-thyroid (HPT) axis, composed by thyrotropin-…
During the endotoxemia acutely induced by the lipopolysaccharide (LPS) (100micrograms/kg), we observed hypophagia and reduced body weight gain, in addition to the increased production of inflammatory cytokines. These responses are associated with increased plasma leptin levels. However, animals treated with repeated doses of LPS did not show hypophagia and reduced body weight gain, indica…
| 1 / 1 | Ongoing research grants |
| 10 / 8 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 22 / 10 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 37 / 22 | All research grants and scholarships |
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BORGES, BEATRIZ C.; ELIAS, CAROL F.; ELIAS, LUCILA L. K.. PI3K signaling: A molecular pathway associated with acute hypophagic response during inflammatory challenges. Molecular and Cellular Endocrinology, v. 438, n. C, p. 36-41, DEC 15 2016. (13/09799-1, 13/03915-0)
RIVAS, PRISCILA M. S.; VECHIATO, FERNANDA M. V.; BORGES, BEATRIZ C.; RORATO, RODRIGO; ANTUNES-RODRIGUES, JOSE; ELIAS, LUCILA L. K.. Increase in hypothalamic AMPK phosphorylation induced by prolonged exposure to LPS involves ghrelin and CB1R signaling. Hormones and Behavior, v. 93, p. 166-174, JUL 2017. (13/09799-1, 12/18179-4, 13/03915-0)
BORGES, BEATRIZ C.; GARCIA-GALIANO, DAVID; CRUZ-MACHADO, SANSERAY DA SILVEIRA; HAN, XINGFA; GAVRILINA, GALINA B.; SAUNDERS, THOMAS L.; AUCHUS, RICHARD J.; HAMMOUD, SAHER S.; SMITH, GARY D.; ELIAS, CAROL F.. Obesity-Induced Infertility in Male Mice Is Associated With Disruption of Crisp4 Expression and Sperm Fertilization Capacity. Endocrinology, v. 158, n. 9, p. 2930-2943, SEP 2017. (12/16536-4, 13/03915-0)
RORATO, RODRIGO; BORGES, BEATRIZ DE CARVALHO; UCHOA, ERNANE TORRES; ANTUNES-RODRIGUES, JOSE; ELIAS, CAROL FUZETI; KAGOHARA ELIAS, LUCILA LEICO. LPS-Induced Low-Grade Inflammation Increases Hypothalamic JNK Expression and Causes Central Insulin Resistance Irrespective of Body Weight Changes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 18, n. 7, JUL 2017. (13/09799-1, 12/18179-4)
GONCALVES, GABRIEL HENRIQUE MARQUES; TRISTAO, SABRINA MARA; VOLPI, RAFAELLA EDUARDA; ALMEIDA-PEREIRA, GISLAINE; DE CARVALHO BORGES, BEATRIZ; DONATO, JR., JOSE; DE CASTRO, MARGARET; ANTUNES-RODRIGUES, JOSE; ELIAS, LUCILA LEICO KAGOHARA. STAT3 but Not ERK2 Is a Crucial Mediator Against Diet-Induced Obesity via VMH Neurons. Diabetes, v. 70, n. 7, p. 1498-1507, JUL 2021. (14/17248-8, 18/10090-0, 13/09799-1)
ALENCAR, M. A. V. S. D.; DE ARAUJO, I. M.; PARREIRAS-E-SILVA, L. T.; NOGUEIRA-BARBOSA, M. H.; SALGADO JR, W.; ELIAS JR, J.; SALMON, C. E. G.; DE PAULA, F. J. A.. Hashtag bone: detrimental effects on bone contrast with metabolic benefits one and five years after Roux-en-Y gastric bypass. Brazilian Journal of Medical and Biological Research, v. 54, n. 12, 2021. (16/18574-1, 18/18071-5)
GARCIA-GALIANO, DAVID; BORGES, BEATRIZ C.; DONATO, JR., JOSE; ALLEN, SUSAN J.; BELLEFONTAINE, NICOLE; WANG, MENGJIE; ZHAO, JEAN J.; KOZLOFF, KENNETH M.; HILL, JENNIFER W.; ELIAS, CAROL F.. PI3K alpha inactivation in leptin receptor cells increases leptin sensitivity but disrupts growth and reproduction. JCI INSIGHT, v. 2, n. 23, DEC 7 2017. (13/03915-0)