CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Pharmacist-Biochemist (São Paulo State University "Júlio de Mesquita Filho" - FCF-UNESP) (2016), with an exchange program at the University of Beira Interior (Covilhã, Portugal) in 2015. Master's degree (2018) and Ph.D. (2022) in Sciences from the University of São Paulo (FCFRP-USP). International traineeship at Leiden University (Leiden Academic Centre for Drug Research, Leiden, Netherlands) in 2018, at the University of Washington (Department of Pharmaceutics, Seattle, United States) in 2022, and a postdoctoral fellowship (University of Washington) in 2023 in the area of Pharmacometrics, combining modeling and simulation techniques in physiology-based pharmacokinetics (PBPK), population pharmacokinetics (PopPK), and in vitro-in vivo correlation (IVIVE). Currently, a faculty member at the School of Pharmaceutical Sciences, University of São Paulo (FCF-USP). Works in the fields of Pharmacotherapy and Clinical Pharmacology, focusing on pharmacokinetics, pharmacokinetic-pharmacodynamic relationships (PK-PD), and drug-disease interactions. (Source: Lattes Curriculum)
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The investigation of the role of Organic Anion Transporters (OAT) 1 and 3 in the pharmacological therapy as well as factors influencing its activities and/or expression, has been recommended because of its important contribution in the renal excretion of drugs. This project aims to investigate the influence of Pyelonephritis, a bacterial infection with an important inflammatory component …
The organic cation transporter 2 (OCT2), expressed at the basolateral membrane of proximal tubule of the kidneys, plays an important role in the elimination of several clinically available drugs. Gabapentin (GBP), anticonvulsant used to treat neuropathic pain, is partially eliminated by renal active secretion via OCT2. The experimental diabetes mellitus (EDM) induced by streptozotocin (ST…
Pregnancy and inflammation (due to infectious diseases) are each known to alter drug pharmacokinetics (PK) by changing the expression and activity of transporters and/or drug-metabolizing enzymes (e.g. CYPs). Quantifying changes in drug PK caused by pregnancy and/or cytokines (elevated during inflammation) is important for rational design of dosing regimens of drugs for pregnant women wit…
Paediatric doses are often derived from adult dosages based on bodyweight. However, growing up is related not only to an increased bodyweight but changes in intrinsic activity and expression of drug-metabolizing enzymes, receptors and transporters. Linearly extrapolating the adult dose to children based on bodyweight may result in intoxication, therapeutic failure or even fatalities. Ther…
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