Abstract
Five-membered N-heterocycles are ubiquitous substructures in drugs and biologically active natural products. Pyrrolidines, pyrroles, pyrrolines and gamma-lactams are present in pharmaceuticals such as Doxapram, Brivaracetam, Atorvastatin, Clindamycin and Tolmetin, commonly used as respiratory stimulant, anticonvulsant, for prevention of cardiovascular disease, antibiotic e anti-inflammato…