Noemia Aparecida Partelli Mariani in research grants and scholarships supported by FAPESP.
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Although male contraceptive options are limited to condoms and vasectomy, almost 30% of couples rely on them as their main contraceptive choice. New male contraceptives are under development to fulfill this unmet need, profoundly impacting family planning and health. EPPIN (epididymal protease inhibitor) is a sperm protein with crucial roles in male fertility. EPPIN works as a central hub…
EPPIN (Epididymal protease inhibitor) is a sperm surface protein recognized as a target for the development of male contraceptive drugs, due to its critical role on sperm function. EPPIN is expressed in the testis and epididymis, and is found on the human sperm surface, where it inhibits sperm motility after ejaculation via interaction with the seminal plasma protein SEMG1 (semenogelin-1)…
The EPPIN gene (Epididymal protease inhibitor) is a member of the superfamily of protease inhibitors, recognized as a promising target for male contraception due to its critical role on fertility. EPPIN is expressed and secreted by Sertoli cells and epididymal epithelial cells and covers the surface of human spermatozoa, where it works as a modulator of sperm motility after ejaculation by…
After ejaculation, mammalian spermatozoa need to undergo several molecular and biochemistry changes to fertilize the egg. The major protein of the seminal plasma is semenogelin 1 (SEMG1), which plays several roles in the modulation of sperm function, such as motility, hyperactivation and capacitation. SEMG1 modulates sperm function by interacting with EPPIN, a cysteine-rich protein found …
| 1 / 1 | Ongoing scholarships in Brazil |
| 2 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 4 / 4 | All Scholarships |
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