CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
PhD student at the Laboratory of Protein Crystallography (Faculty of Pharmaceutical Sciences of Ribeirão Preto, USP). Pharmacist graduated from the University of São Paulo (2022), and Technician in Chemistry graduated from Etec Tiquatira (2016). Scientific Initiation concluded in the areas of structural and molecular biology at the Laboratory of Structure and Evolution of Proteins (Institute of Biomedical Sciences, USP), and cell biology at the Laboratory of Vascular Biology (InCor, Hospital das Clínicas). (Source: Lattes Curriculum)
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The Dihydroorate Dehydrogenase (DHODH) is present in bacteria, fungi, animals, and plants, being an important target of study. It is an essential enzyme for the maintenance of cellular homeostasis, and responsible for the conversion of dihydroorate into orotate, in the fourth enzymatic step of the de novo pyrimidine nucleotide synthesis pathway. This project aims to develop potent inhibit…
Protein Disulfide Isomerase-A1 (PDIA1) is a dithiol-disulfide oxidoreductase chaperone with a major canonical function of redox protein folding (disulfide bond formation/isomerization) in nascent proteins at the endoplasmic reticulum (ER). Thus,PDIA1 exerts a central role in ER-associated proteostasis and redox balance. The presence of PDIA1 in different subcellular locations has been doc…
Leptospirosis is a disease of broad incidence in tropical countries and your transmission is caused by species of Leptospira genus, and have resistant to environmental changes, such as temperature and pH. It's believed that this resistance is in somehow related to the process of regulation of the second bacterial messenger c-di-GMP by DGC activity in proteins with GGDEF domains. In this p…
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