Abstract
Prolyl Oligopeptidase (POP; EC3.4.21.26) is a serine peptidase present in various tissues and cell types. Some studies show that it is highly expressed in GABAergic and cholinergic interneurons of the thalamus and cortex. A distinguishable POP feature is the cleavage after proline residues in oligopeptides smaller than 3kDa. Recent studies have indicated that the major POP action is on in…