Abstract
The SNS is known to negatively regulate bone mass, acting via receptor Beta2-adrenergic receptors (B2-AR). Our group demonstrated that alpha2A (a2A-AR) and a2C (a2C-AR) adrenergic receptors also mediate negative actions of the SNS in the bone mass. In addition, we found that mice with isolated gene inactivation of a2A-AR and a2C-AR (a2A-AR-/- and a2C-AR-/-) exhibit lower body length and p…