Abstract
Rare inactivating allelic variants in the MKRN3 and DLK1 genes have been identified as monogenic causes of central precocious puberty (CPP). Patients with familial CPP and DLK1 mutations have shown a higher frequency of metabolic alterations in adulthood. Similar to this finding, studies have shown that Dlk1-deficient mice also have metabolic alterations. The association between puberty a…