CV Lattes
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Universidade Federal de São Carlos (UFSCAR). Centro de Ciências Biológicas e da Saúde (CCBS) (Institutional affiliation from the last research proposal) Birthplace: Brazil
B.Sc. in Animal Science - University of São Paulo. PhD in Medical Physiopathology - State University of Campinas, with research training at University of Oxford, UK. Post-doctoral researcher at University of São Paulo. Sabbatical period at University of Cambridge, UK. Currently is Associate Professor in the Department of Genetics and Evolution, Federal University of São Carlos. Our research is focused on understanding factors regulating female fertility in mammals, with an emphasis on the role of mitochondria in determining oocyte quality and leading to health embryos and offspring. Specifically, we are working to (i) characterize mitochondrial function and dynamics during oocyte formation and how it connects to female fertility; (ii) determine how oocyte mitochondria contribute to abnormalities in offspring in cases of mothers with diseases such as obesity and other metabolic disorders; (iii) unravel the mechanisms shaping mitochondrial inheritance and develop new tools to enable mitochondrial DNA editing in oocytes and embryos and modulation of mitochondrial DNA inheritance during mother-to-offspring transmission. (Source: Lattes Curriculum)
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A biosafety level 2 (class 2) animal house is a certified facility for conducting research with moderate-risk biological agents, such as Genetically Modified Organisms (GMOs) of risk class 2 and biological agents that cause infections in humans or animals. The Federal University of São Carlos (UFSCar) does not have an animal house with these characteristics, which represents a significant…
During folliculogenesis, the maternal gamete (oocyte) undergoes important changes needed for conclusion of meiosis, fertilization and embryogenesis. Among these changes we highlight a significant alteration in mitochondrial dynamics, resulting in extensive fragmentation of the mitochondrial network and, thereby, segregation of mitochondrial DNA (mtDNA) molecules across thousands of mitoch…
Research in the field of cell biology is essentially based on fluorescence emission as a key marker of cell structures, molecules, and biological responses. Image detection by fluorescence relies on instruments capable of emitting and detecting light simultaneously at different wavelengths, in three dimensions, with speed, sensitivity and resolution compatible with biological events or st…
(Only some records are available in English at this moment)
Bovine in vitro embryo production (IVP) is one of the most used reproductive biotechnologies, being Brazil raked in the runner-up position among countries making use of this technology. Embryo cryopreservation is required for storing exceeding embryos and transport to other regions/countries, but the efficiency of this technology is considered low, with a range of outcomes following cryop…
Growing evidence supports that maternal obesity predispose the offspring to cardiometabolic syndromes. In this respect, previous reports have indicated a possible role for mitochondrial and endoplasmic reticulum (ER) dysfunction in oocytes. In parallel, studies involving humans and mice have found that metabolic disease represses mitofusin 2 (MFN2) expression, further impacting mitochondr…
There is evidence of a purifying filter acting in the female germline to prevent expansion of deleterious mutations in the mitochondrial DNA (mtDNA). Given our poor understanding of this filter, here we investigate the competence of the mouse embryo to eliminate dysfunctional mitochondria. Towards that, mitochondria were damaged by photoirradiation of NZB/BINJ zygotes loaded with chlorome…
(Only some records are available in English at this moment)
The human mitochondrial DNA (mtDNA) is a circular, multi-copy, extra-nuclear genome of 16.6 kb comprising two non-coding regions and 37 genes that are essential for mitochondrial function. Subjected to a high mutation rate and due to the absence of recombination, mutant and wild-type mtDNA molecules normally co-exist in the cell determining a condition known as heteroplasmy. Normally, the…
Recent evidence shows that maternal obesity predisposes offspring to metabolic disturbs including obesity, diabetes and cardiac diseases. The presence of dysfunctional mitochondria in the oocyte of obese/diabetic females is pointed as a potential mechanism to explain these phenotypes once damaged/dysfunctional mitochondria may be passed down to offspring and contribute with the onset of m…
The human mitochondrial DNA (mtDNA) contains 10-15 times more single nucleotide variants (mtSNVs) than the nuclear DNA, which can cause extremely severe pathologies and influence a wide range of physiological functions, such as kidney and liver function, height, and even longevity. Since each cell contains from hundreds to thousands of copies of mtDNA, mutant and wild-type molecules coexi…
(Only some records are available in English at this moment)
The present proposal is supported by our aim to contribute with the scientific advertisement, in particular, of research carried out in the Laboratory of Genetics and Biotecnology (LaGenBio), at Federal University of Sao Carlos (UFSCar). We seek with this to raise awareness and engage different sectors of our society about the roles of scientific research and the university. The planned n…
(Only some records are available in English at this moment)
Single nucleotide variations (mtSNV) are present in the human mitochondrial DNA (mtDNA) ranging in frequency from ~10 to 15 fold higher than that seen in the nuclear DNA, being able to affect mitochondrial function and different physiological parameters, beside determining important rare diseases. Despite this, little is known about the mechanisms regulating the inheritance of mtSNVs, whi…
Diseases caused by mutations in mitochondrial DNA (mtDNA) affect ~1 in 4,300 people. In addition, almost every person carries very low levels of mutated mtDNA, which may be transmitted down to the maternal lineage and associate with late-onset degenerative diseases. Transmission of mutated mtDNAs in germ cells relies upon the mitochondrial bottleneck, which results in drastic changes in t…
The determining role of mitochondria in regulating follicular development and oocyte growth is emerging from basic research on model species and clinical studies on female infertility. This new branch of research has been dedicated to deciphering the relationship between oocyte developmental competence and bioenergetics. Mitochondrial activity depends, among other things, on its organelle…
Diseases caused by mutations in mitochondrial DNA (mtDNA) affect ~1 in 4,300 people. In addition, almost every person carries very low levels of mutated mtDNA, which may be transmitted down to the maternal lineage and associate with late-onset degenerative diseases. Inheritance of mutated mtDNAs in germ cells relies upon the mitochondrial bottleneck, which results in drastic changes in th…
(Only some records are available in English at this moment)