CV Lattes
ResearcherID
ORCID
Google Scholar Citations
Universidade Federal de São Carlos (UFSCAR). Centro de Ciências Biológicas e da Saúde (CCBS) (Institutional affiliation from the last research proposal) Birthplace: Brazil
B.Sc. in Animal Science - University of São Paulo. PhD in Medical Physiopathology - State University of Campinas, with research training at University of Oxford, UK. Post-doctoral researcher at University of São Paulo. Sabbatical period at University of Cambridge, UK. Currently is Associate Professor in the Department of Genetics and Evolution, Federal University of São Carlos. Our research is focused on understanding factors regulating female fertility in mammals, with an emphasis on the role of mitochondria in determining oocyte quality and leading to health embryos and offspring. Specifically, we are working to (i) characterize mitochondrial function and dynamics during oocyte formation and how it connects to female fertility; (ii) determine how oocyte mitochondria contribute to abnormalities in offspring in cases of mothers with diseases such as obesity and other metabolic disorders; (iii) unravel the mechanisms shaping mitochondrial inheritance and develop new tools to enable mitochondrial DNA editing in oocytes and embryos and modulation of mitochondrial DNA inheritance during mother-to-offspring transmission. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Research in the field of cell biology is essentially based on fluorescence emission as a key marker of cell structures, molecules, and biological responses. Image detection by fluorescence relies on instruments capable of emitting and detecting light simultaneously at different wavelengths, in three dimensions, with speed, sensitivity and resolution compatible with biological events or st…
Mitochondria are the main source of energy within cells. They are made from over ~1100 proteins which are coded by two different genomes: nuclear DNA and mitochondrial DNA (mtDNA). MtDNA is only inherited from our mother, and codes for 13 mitochondrial proteins that are essential for cell energy production. In humans, mtDNA varies considerably between different people (called mtDNA single…
Bovine in vitro embryo production (IVP) is one of the most used reproductive biotechnologies, being Brazil raked in the runner-up position among countries making use of this technology. Embryo cryopreservation is required for storing exceeding embryos and transport to other regions/countries, but the efficiency of this technology is considered low, with a range of outcomes following cryop…
Growing evidence supports that maternal obesity predispose the offspring to cardiometabolic syndromes. In this respect, previous reports have indicated a possible role for mitochondrial and endoplasmic reticulum (ER) dysfunction in oocytes. In parallel, studies involving humans and mice have found that metabolic disease represses mitofusin 2 (MFN2) expression, further impacting mitochondr…
This proposal is based on previous findings of M. Chiaratti's group, which with the expertise provided by the H. Clarke's group seeks to characterize mitochondrial dynamics in oocytes in greater depth, with potential implications to human welfare and health. The proposed scientific activities will investigate three hypotheses in mice: 1) Mfn1 conditional knockout (cKO) inhibits the P13K1A…
(Only some records are available in English at this moment)
Mitochondria are the principal source of cellular energy which is produced by oxidative phosphorylation (OXPHOS) leading to the production of adenosine triphosphate (ATP). Thirteen essential OXPHOS proteins are synthesised within the mitochondrion from mitochondrial DNA (mtDNA) which is exclusively inherited down the maternal line. MtDNA is highly polymorphic in humans, but the single nuc…
Mitochondria are the principal source of cellular energy which is produced by oxidative phosphorylation (OXPHOS) leading to the production of adenosine triphosphate (ATP). Thirteen essential OXPHOS proteins are synthesised within the mitochondrion from mitochondrial DNA (mtDNA) which is exclusively inherited down the maternal line. MtDNA is highly polymorphic in humans, but the single nuc…
Growing evidence supports that maternal obesity predispose the offspring to metabolic syndromes. In this respect, previous reports have indicated a possible role for mitochondrial and endoplasmic reticulum (ER) dysfunction in oocytes. In parallel, studies in humans and mice have found that metabolic diseases repress mitofusin 2 (MFN2) expression, further impacting mitochondria-ER contact …
(Only some records are available in English at this moment)
The present proposal is supported by our aim to contribute with the scientific advertisement, in particular, of research carried out in the Laboratory of Genetics and Biotecnology (LaGenBio), at Federal University of Sao Carlos (UFSCar). We seek with this to raise awareness and engage different sectors of our society about the roles of scientific research and the university. The planned n…
(Only some records are available in English at this moment)
Diseases caused by mutations in mitochondrial DNA (mtDNA) affect ~1 in 4,300 people. In addition, almost every person carries very low levels of mutated mtDNA, which may be transmitted down to the maternal lineage and associate with late-onset degenerative diseases. Transmission of mutated mtDNAs in germ cells relies upon the mitochondrial bottleneck, which results in drastic changes in t…
The determining role of mitochondria in regulating follicular development and oocyte growth is emerging from basic research on model species and clinical studies on female infertility. This new branch of research has been dedicated to deciphering the relationship between oocyte developmental competence and bioenergetics. Mitochondrial activity depends, among other things, on its organelle…
Diseases caused by mutations in mitochondrial DNA (mtDNA) affect ~1 in 4,300 people. In addition, almost every person carries very low levels of mutated mtDNA, which may be transmitted down to the maternal lineage and associate with late-onset degenerative diseases. Inheritance of mutated mtDNAs in germ cells relies upon the mitochondrial bottleneck, which results in drastic changes in th…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 10 / 8 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 19 / 16 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 40 / 35 | All research grants and scholarships |
| Associated processes | |