Mayara Cristina Vieira Machado in research grants and scholarships supported by FAPESP.
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The fellow will study the transcriptional profile involving mRNAs and miRNAs of thymocytes that physically interact with Aire wild-type (wt) or Aire mutant mTECs cells (adhesion mTECs-thymocytes in vitro). As discussed in the thematic project, the interaction between thymocytes and epithelial thymic cells (TECs) is essential for the development of these two cell types. To test this hypoth…
The Autoimmune regulator (Aire) gene (human chromosome 21q22.3 and Mus musculus 10qC1), is a controller of central immune tolerance and the emergence of autoimmune diseases. The Aire sequence presents ~ 80% man-mouse similarity and this gene regulates the transcription of peripheral tissue autoantigen genes (PTAs) in medullary thymic epithelial cells (mTECs). This phenomenon was termed pr…
| 2 / 2 | Completed scholarships in Brazil |
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