Graduated in Biological Sciences at the Universidade de São Paulo in 2019. During her scientific initiation (2018-2020), she characterized a protein secreted by Salmonella Typhimurium by the Type VI Secretion System (T6SS). She is currently a Master's student at the Institute of Biomedical Sciences at the Universidade de São Paulo and studies the contribution of Hcps proteins to the Salmonella Typhimurium pathogenesis SPI-6 T6SS-dependent . (Source: Lattes Curriculum)
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Salmonella Typhimurium genome encodes a type VI secretion system (T6SS) within the SPI-6 pathogenicity island important for the establishment of mouse infections. S. Typhimurium SPI-6 T6SS was shown to be important during competitions with bacteria from the intestinal microbiota, and is also activated during infections of macrophages in vitro. Hcp proteins (hemolysin coregulated protein) …
The genome of Salmonella Typhimurium encodes a type VI secretion system (T6SS) inside the Salmonella pathogenicity island (SPI-6). In Salmonella Gallinarum the T6SS is encoded from SPI-19. Genes located inside SPI-6 T6SS from S. Typhimurium are activated during late stages of infection, while SPI-19 T6SS from S. Gallinarum are activated early during the infection of macrophages. The signi…
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SIBINELLI-SOUSA, STEPHANIE; DE ARAUJO-SILVA, ANDRE LUIZ; HESPANHOL, JULIA TAKUNO; ETHEL, BAYER-SANTOS. Revisiting the steps of Salmonella gut infection with a focus on antagonistic interbacterial interactions. FEBS Journal, OCT 2021. (18/04553-8, 19/27644-1, 18/25316-4, 17/02178-2, 21/02536-1)
SIBINELLI-SOUSA, STEPHANIE; HESPANHOL, JULIA T.; NICASTRO, GIANLUCCA G.; MATSUYAMA, BRUNO Y.; MESNAGE, STEPHANE; PATEL, ANKUR; DE SOUZA, ROBSON F.; GUZZO, CRISTIANE R.; BAYER-SANTOS, ETHEL. A Family of T6SS Antibacterial Effectors Related to L,D-Transpeptidases Targets the Peptidoglycan. CELL REPORTS, v. 31, n. 12, JUN 23 2020. (18/04553-8, 17/02178-2, 16/09047-8, 19/00195-2, 17/17303-7, 18/25316-4, 16/00458-5, 18/13819-1)
SIBINELLI-SOUSA, STEPHANIE; HESPANHOL, JULIA TAKUNO; BAYER-SANTOS, ETHEL. Targeting the Achilles' Heel of Bacteria: Different Mechanisms To Break Down the Peptidoglycan Cell Wall during Bacterial Warfare. Journal of Bacteriology, v. 203, n. 7, APR 2021. (18/25316-4, 18/04553-8, 17/02178-2, 19/27644-1)
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