CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Centro de Biologia Molecular e Engenharia Genética (CBMEG) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Rafael is the Principal Investigator at the Structural Genomics Consortium (SGC) laboratory at the University of North Carolina, where he is an Associate Professor at the School of Pharmacy. Trained in biochemistry and protein crystallography, Rafael obtained his PhD from Rice University (TX-USA) in 2005 and has worked as a postdoctoral researcher in the USA, New Zealand, and Australia. In 2015, he joined the SGC laboratory at the State University of Campinas (UNICAMP), São Paulo, Brazil, where he served as Chief Scientist between 2018 and 2020. Since 2018, he has been a collaborator and Principal Investigator at the Center for Medicinal Chemistry (CQMED) at UNICAMP. Rafael's main scientific interests are: 1) identifying and validating potential therapeutic targets for proteins related to human diseases; and 2) utilizing tools of chemical biology to elucidate the function of poorly studied proteins. At SGC-UNC, Rafael leads efforts to identify hits for human and viral proteins using DNA-encoded libraries (DEL) in combination with machine learning. (Source: Lattes Curriculum)
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Many of the discoveries from the rapidly expanding genomic sciences are not effectively utilized in medicine, agriculture and industry. This is partly because of the disconnection between scientists in different disciplines, and because much of the translational research done in both industry and academia is patent-protected and not published in a timely manner. This INCT proposal address…
Breast Cancer is the most common among women. There are some therapies being used, however the high degree of heterogenicity makes it necessary the search for new targets and drugs. The Lemur Tyrosine Kinase 3 (LMTK3) was found in a silencing RNA screening as a promising target for this disease. It is an estrogen receptor modulator and it inhibition has antitumoral effects even against tr…
The growing number of bacteria resistant to current antibiotics poses a serious threat to public health services worldwide. At the same time, large pharmaceutical companies have exited this clinical area. A major obstacle in antibiotic discovery is that potent biochemical inhibitors to target essential enzymes often lack in-cell activity. This lack bactericidal activity can be linked to p…
| 1 / 1 | Completed research grants |
| 2 / 2 | Completed scholarships in Brazil |
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