Abstract
The Rho GTPase family of proteins consists of 20 members whose deregulation is frequently found in hematological neoplasms. RhoA, RhoB and RhoC (also known as Rho proteins) form a specific subfamily of highly homologous Rho GTPases whose functions in normal and leukemic hematopoiesis remain to be elucidated. Our hypothesis is that Rho proteins have specific and essential functions in hem…