CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor of Pharmacy, UFRGS, Porto Alegre, Brazil (2007)PhD, St. Vincent's Institute, University of Melbourne, Australia (2013)Postdoctoral Research Fellow, Genome Damage and Stability Centre, University of Sussex, UK (2014-2018)Assistant Professor, Department of Biochemistry, University of São Paulo (2018-2023)Assocaite Professor, Department of Biochemistry, University of São Paulo (2023-current)Studies cellular mechanisms of DNA repair and DNA damage signalling mediated by a post-translational modification termed ADP-ribosylation. Has a special interest in human genetic disorders caused by mutations in these processes and, more recently, in the role of ADP-ribosylation in the context of the cellular response to viral infections. (Source: Lattes Curriculum)
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Genomic instability is the main driving force for cancer onset and progression, underlies the ageing process and is associated with neurodegenerative disease. Protein post-translational modification by NAD+-derived ADP-ribose moieties plays central roles in orchestrating the cellular DNA damage response, but most of the human enzymes that catalyse this modification, as well as the hydrola…
The search for anti-coronaviral treatments is largely focused on inhibitors of the viral polymerase or one of the viral proteases. However, the viral macrodomain contained in non-structural protein 3 (Nsp3) is an attractive and underexplored target, as it has a druggable catalytic pocket, is required for viral replication and is part of an important mechanism of active viral repression of…
Genomic instability is the main driving force for cancer onset and progression, underlies the ageing process and is associated with neurodegenerative disease. Protein post-translational modification by NAD+-derived ADP-ribose moieties plays central roles in orchestrating the cellular DNA damage response, but most of the human enzymes that catalyze this modification, as well as the hydrola…
Chaperone-mediated autophagy (CMA) is a selective process of intracellular protein degradation, in which a pentapeptide motif similar to KFERQ is recognized by cytosolic chaperones, that direct the substrate to the lysosomal surface, where the LAMP2A receptor allows cargo translocation across the lysosomal membrane. CMA plays a crucial role in maintaining cellular homeostasis, regulating …
Chaperone-mediated autophagy (CMA) is a proteolytic system essential for maintaining cellular homeostasis, through which only intracellular proteins bearing a specific motif (KFERQ-like) are selectively degraded in lysosomes. This is accomplished through the coordinated action of cytosolic chaperones and a translocation complex of proteins located at the lysosome membrane. In addition to …
The virus that causes severe acute respiratory syndrome 2 (SARS-CoV-2) has triggered one of the biggest pandemics seen by humanity, leading to millions of deaths worldwide. Although the development of vaccines has taken place in record time and has provided a substantial reduction in the number of deaths from COVID-19, the development of drugs with antiviral activity remains a necessity, …
DNA damage activates pleiotropic cellular responses such as cell cycle arrest and senescence, but can also induce an inflammatory interferon response, which is an anti-viral pathway activated by the presence of DNA in the cytoplasm. We have identified PARP9 and DTX3L, two proteins that form a heterodimer in cells and are expressed from a shared interferon-responsive promoter, in a screen …
Post-translational modifications, such as ubiquitination and ADP-ribosylation (the addition of ADP-ribose units catalyzed by enzymes of the PARP family), have a central role in cellular signaling cascades, such as DNA damage repair or the innate immune response. The PARP9/DTX3L heterodimer possesses both ADP-ribosyltransferase and E3 ubiquitin ligase activity and has been implicated in DN…
DNA damage signalling and repair are regulated by a variety of post-translational modifications, including ubiquitination and ADP-ribosylation. We have previously identified the ADP-ribosyl transferase PARP9 and the ubiquitin ligase DTX3L in an in vitro screen for factors that bind to ADP-ribosylated Histone H2B, which is a PARP3 catalysed modification induced by DNA damage. Here, we will…
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Autophagy is a catabolic process, highly conserved in eukaryotes, that mediates the degradation of intracellular components and pathogens in lysosomes. Based on the mechanism used for cargo delivery in lysosomes, there are three main types of autophagy: microautophagy (MI), macroautophagy (MA) and chaperone-mediated autophagy (CMA). CMA is selective for degradation of proteins bearing a p…
During viral infections, one of the strategies employed by the innate immune system is the so-called interferon response (IFN), which induces the expression of several anti-viral proteins to reduce viral replication and pathogenesis. This host response includes a class of enzymes called poly(ADP-ribose) polymerases (PARPs) that catalyse the post-translational modification of proteins with…
| 1 / 1 | Ongoing grants |
| 2 / 2 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 10 / 10 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 18 / 18 | All research grants and scholarships |
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