Abstract
The R2TP co-chaperone complex (Rvb1, Rvb2, Tah1 and Pih1/ Nop17) is evolutionarily conserved and mediates the interaction of the Hsp90 chaperone with target proteins and complexes. R2TP-Hsp90 assists maturation of several protein complexes, such as box C/D snoRNPs, U4 and U5 snRNP and RNA polymerase II. Nop17 plays a central role in the complex because it acts on the structural cohesion o…