Abstract
The BTBR ob/ob mice (black and tan, obese, tufted) are characterized by a mutation on the leptin gene (Lep ob ) that makes it knockout for this gene. Due to this mutation, BTBR mice show a number of characteristics, such as:hyperfagia, hyperglycemia, glucose intolerance, hyperisulinism,hypertriglyceridemia, impaired healing, albuminuria, hypothermia, andincreased production of pituitary a…