CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Flávia Barrio Lopes has a Bachelor's degree in Pharmacy (2020) and a Master's degree (2023) from the Federal University of São Paulo. She has professional experience in the Pharmacy field, with an emphasis on public health, where she worked with the dispensing of medicines to users of the Unified Health System of São Bernardo do Campo. She participated in a scientific initiation project in the Synthesis of Bioactive Molecules group (SiMBio), from the Laboratory of Natural and Synthetic Inputs (LINS) of the Federal University of São Paulo. She completed her Master's degree in the Graduate Program in Pharmaceutical Sciences at Unifesp, working in the Medicinal Chemistry field with the design, synthesis and evaluation of histaminergic receptor ligands and cholinesterase inhibitors with chelating properties associated. Currently, she participates in the SiMBio group, with a project related to the design of multitarget ligands directed to the CNS. (Source: Lattes Curriculum)
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The design of molecules able to interact with more than one target simultaneously has been explored as a strategy in the treatment of complex diseases, such as neurodegenerative diseases, in which different pathophysiological mechanisms are involved. Many neurodegenerative diseases, such as Alzheimer's disease, dementia with Lewy bodies, among others, are characterized by the accumulation…
The interest in multi-target drugs, i.e., molecules capable of interacting in more than one target simultaneously, has been growing in recent years as a new way to treat complex diseases, which involve different signaling pathways, connected to each other. This is the case for neurodegenerative diseases (for example, Alzheimer's disease), which involve changes in cognition-related pathway…
Interest in multimarket drugs, i.e. molecules capable of interacting with more than one target simultaneously, has been growing in recent years as a new strategy to treat complex diseases that involve different interconnected signaling pathways. This is the case for neuropsychiatric diseases such as Alzheimer's (AD) and Parkinson's diseases, schizophrenia, depression, epilepsy among other…
The discovery and development pipeline for new drug candidates is a challenging process, especially when considering compounds designed to simultaneously act on two or more targets. In this context, two set of compounds were designed and prepared as histamine H3 receptor (H3R) antagonists and glutaminyl cyclase (QC) inhibitors, two targets for therapeutic applications in neurodegenerative…
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