CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Medicine from the University of São Paulo (1972 ), M.Sc. in Physiology from the University of São Paulo (1978) Ph.D. in Physiology from the University of São Paulo (1982). Research Fellow at Harvard University (1984). Associate Professor, Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, University of São Paulo (1992). Full Professor and Chief of Nephrology, Department of Internal Medicine, Faculty of Medicine, University of São Paulo, since 2005. Experienced in Clinical Medicine and Nephrology, mainly in the subareas of chronic nephropathy and diabetic nephropathy. Head of the Laboratory of Renal Pathophysiology of the Nephrology Department of the Faculty of Medicine, USP from 1995 to 2018. Coordinator of two FAPESP Thematic Projects (1992-1997 and 2013-2018). Responsible from 1992 to 2016 for the Nephrology Chapter of the Course on Physiological Basics of Clinical Medicine, taught to students of the Medicine Course at the Faculty of Medicine of USP. General Coordinator of that course (2006-2016). Currently responsible for the Curricular Unit 11 of the Medicine Course at FMUSP, coordinating directly two Disciplines, MSP2112 and MSP2113, in addition to administering classes for two other Disciplines, 6700001 and 6700002 (Source: Lattes Curriculum)
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6-nitrodopamine (6-ND), a product of the nitric oxide (NO) dependent nitration of dopamine (DA), produced endogenously. Increased evidence shows its role as the most potent mediator of in vivo and in vitro chronotropism in rats, and the spasmogenic activity of the vas deferens in rats and humans. In other tissues of the genitourinary tract, the production, release and function of 6-ND is …
The endothelium is an organ capable of regulating vascular tone through the release of endothelium-derived relaxing factors such as nitric oxide, prostacyclin, etc., or endothelium-derived contracting factors as endothelins, prostanoid. In addition, the current physiological concept poses that such regulation can also occur through the release of exclusively neural-derived catecholamines.…
Chronic Kidney Disease (CKD) involves the participation of a series of inflammatory events that culminate in fibrosis of the renal parenchyma. The reasons why these processes, which involve the activation of phenomena related to adaptive immunity, are triggered in the absence of microbial antigens or other foreign proteins are uncertain. With the new knowledge about the innate immunity, a…
In recent years, several research groups in Brazil and abroad, including ours, have consistently shown the role of the inflammatory response in some kidney diseases. Despite the advances have been most prominent in animal models, the strongly generated data indicate that acute and chronic renal lesions are influenced by the immune response, up to now considered sterile in all compartments…
(Only some records are available in English at this moment)
The 6-nitrodopamine (6-ND), a product of nitric oxide (NO)-dependent "nitration" of dopamine (DA), is produced endogenously, and increasing evidence shows its role as the most potent mediator of in vivo and in vitro chronotropism in rats, as well as the spasmogenic activity of the vas deferens in rats and humans. Despite being the catecholamine released in greater quantities from the stud…
6-nitrodopamine (6-ND), a product of the nitric oxide (NO) dependent nitration of dopamine (DA), produced endogenously. Increased evidence shows its role as the most potent mediator of in vivo and in vitro chronotropism in rats, and the spasmogenic activity of the vas deferens in rats and humans. In other tissues of the genitourinary tract, the production, release and function of 6-ND is …
Chronic Kidney Disease (CKD) involves the participation of a series of inflammatory events that culminate with renal interstitial fibrosis even though the process has started exclusively in the glomeruli. One of the major challenges currently encountered by nephrology is to halt the progression of CKD. Proteinuria correlates with the progression of CKD, particularly when caused by glomeru…
It is well known that Chronic Kidney Disease affects approximately 10% of the population around the world. Unfortunately, the understanding of the chronic renal injury mechanisms and how to treat them, are still distant. However, it is known that mechanical factors such as, hypertension and glomerular hypertrophy, and a series of inflammatory events in the loss of renal function are parti…
(Only some records are available in English at this moment)
Fibroblasts are key mediators of fibrosis in the kidney and other organs but their origin during fibrosis is still not completely clear. Activated fibroblasts likely arise from resident quiescent cells via epithelial-to-mesenchymal transition (EMT) and directly from bone marrow. We have studying a third origin of fibroblasts in renal fibrosis: the endothelial-to-mesenchymal transition (En…
Diabetic nephropathy (DN) is one of the most important causes of end-stage renal disease around the world. The mechanisms that lead to the development of DN are complex, and despite progress in recent decades, are still far from being fully understood. Inflammation is involved in both the pathogenesis and progression of DN. There is evidence that activation of innate immunity by diabetes …
The excess dietary adenine (ADE) intratubular promotes precipitation of crystals, leading to a progressive installation of interstitial nephritis and renal function loss. Recent observations indicate that the overhead of ADE in mice in which genes for TLR-2, -4, MyD88, ASC or caspase-1 have been inactivated causes less damage to the kidney compared to administered to wild type mice, sugge…
| 2 / 2 | Ongoing grants |
| 24 / 17 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 20 / 8 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 50 / 31 | All research grants and scholarships |
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