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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Alemanha
Patrick Daniel Varga-Weisz in research grants and scholarships supported by FAPESP.
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Inflammatory bowel disease, such as Crohn's disease (CD, affecting the entire digestive track) and ulcerative colitis (UC, affecting the colon) are dramatically on the rise, especially in the developing world, including Brazil. It is thought that changes in lifestyle, including hygiene and nutrition (such as a change from a vegetable rich diet to a diet rich in fat, meat and carbohydrates…
Inflammatory bowel disease, such as Crohn's disease (CD, affecting the entire digestive track) and ulcerative colitis (UC, affecting the colon) are dramatically on the rise, especially in the developing world, including Brazil. It is thought that changes in life style, including hygiene and nutrition (such as a change from a vegetable rich diet to a diet rich in fat, meat and carbohydrate…
Changes in the packaging of the genomic material, chromatin remodelling processes, play critical roles in gene regulation, including during inflammation. However, how these changes are established and their role during ulcerative colitis, are not well understood. Furthermore, the temporal, cell type specific progression of colitis requires illumination. Here we will use a mouse model for …
Changes in the packaging of the genomic material, chromatin remodelling processes, play critical roles in gene regulation, including during inflammation. However, how these changes are established and their role during Ulcerative Colitis, are not well understood. Furthermore, the temporal, cell type specific progression of Colitis requires illumination. Here we will use a mouse model for …
The human colon provides an ecosystem for a huge number and diversity of microbes, mostly bacteria. These are normally commensal or beneficial, as they play an important role in the digestion of food matter and contribute to the generation of bioactive molecules, such as vitamins and short chain fatty acids. They also have important functions in the defense against pathogens and immunity.…
(Only some records are available in English at this moment)
The short-chain fatty acids (SCFA) produced by the microbiota act in several ways in the gut epithelial cells to regulate gene expression and have been linked to the metabolic state of cells. Histone post-translational modifications (hPTM) have gained prominence with the development of mass spectrometry (MS)-based technologies and the discovery of non-classical acylations such as crotonyl…
The crosstalk between the gut microbiota and host metabolism is a complex and critical process for normal physiology. The intestinal epithelial cells play a fundamental role in this relationship, building mucosal barriers, secreting immunological mediators, and providing bacterial antigens. Furthermore, the microbiome's metabolites also directly affect these cells, driving host metabolism…