Abstract
For many years chloroquine (CQ) was the main drug against blood stages of malaria parasites. Introduced after World War II, the first reports of chloroquine-resistant Plasmodium falciparum appeared in 1957. Resistant parasites quickly spread to all endemic regions, resulting in the total removal of CQ for the treatment of P. falciparum infections in 2000. The first cases of P. vivax chlor…