CV Lattes
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Instituto Ludwig de Pesquisa sobre o Câncer (ILPC). Laboratório de Biologia Molecular e Genômica (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor's degree in Biological Sciences from the Federal University of Paraná (2005), a Master's degree in Biochemistry and Molecular Biology from the University of São Paulo (2010), a Ph.D. in Biochemistry and Molecular Biology from the University of São Paulo, and a Postdoctoral Fellowship from New York University. Has experience in the field of bioinformatics and molecular biology, with an emphasis on gene expression, molecular evolution, and molecular biology of cancer. Currently conducts research in systems biology to uncover mechanisms of cellular adaptation to stress agents and cancer therapies using single-cell RNA-Seq, epigenetic assays (ATAC-Seq), CRISPR screens, and computational biology. (Source: Lattes Curriculum)
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Colorectal cancer is among the three major causes of death by cancer worldwide. The diagnosis is made by histopathological analyses, which are used to define the tumor stages. The treatment is carried out based on the observed tumor stage. For more advanced cases (stages III and IV), it is recommended surgical excision combined with adjuvant chemotherapy. However, colorectal cancer is a d…
Intron origins and evolution have been questioned since their discovery. The intron-late hypothesis argues that introns appeared lately and were inserted in eukaryotic genes, while intron-early theory claims for pre-existing introns in the progenote (common ancestor of prokaryotes and eukaryotes) and they should be lost in prokaryotes by selective pressure to rapid DNA replication dem…
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