Abstract
The expression of key genes required for DNA repair by homology such as Brca1, Mre11, Rad51 and Atm decreases in oocytes during aging, resulting in a progressive increase in double-strand breaks (DSB) in DNA and infertility. In keeping with these findings, our data support that the conditional deletion of Rad51 in mouse oocytes results in subfertility characterized by a significant decrea…