Lucia Rossetti Lopes

• Abstract

  Melanoma is an extremely aggressive type of skin cancer. This characteristic is associated with a greater capacity for tumor metastasis and chemoresistance. Reactive oxygen species (ROS) contribute to the initiation of tumorigenesis, proliferation, invasion and metastasis. Metastasis is one of the most important factors related to a worse prognosis and is responsible for much of the morbi…

  Investigating the redox mechanisms of Vemurafenib resistance in Melanoma cells, AP.R

• Abstract

  Redox homeostasis depends on the regulated production of reactive oxygen species (ROS) via enzymatic sources such as the Nox family NADPH oxidase complex, the main source of ROS in vascular cells. Recent studies from our laboratory disclosed an important role of PDI in the regulation of NADPH oxidase. The important functional effects of PDI in NADPH oxidase in a number of distinct cell ty…

  Role of protein disulfide isomerase in NADPH oxidase dependent ROS generation during hypertension development, AP.R

• Abstract

  Redox homeostasis depends on the regulated production of reactive oxygen species (ROS) via enzymatic sources such as the Nox family NADPH oxidase complex, the main source of ROs in vascular cells. Recent studies from our laboratory disclosed an important role of PDI in the regulation of NADPH oxidase. The important functional effects of PDI in NADPH oxidase in a number of distinct cell ty…

  Regulation of redox homeostasis and integrated stress response by Protein Disulfide Isomerase (PDI): mechanisms and role in the pathophysiology and therapy of vascular diseases, AP.TEM

(Only some records are available in English at this moment)

• Abstract

  Melanoma is the least common skin cancer, though it's the most dangerous if not early detected. This tumor originates from melanocytes, skin pigment cell producers and it can develop in several regions of the body. The prognosis of this cancer type is considered satisfactory in the initial stages, which have decreased the lethality rate and improved patient survival. Nox4 is a component o…

  Role of microRNA-9 in the Inhibition of Nox4 activating protein of epithelial mesenchymal transition in melanoma cells, BP.IC

• Abstract

  Focal adhesions are essential for the cellular anchorage to extracellular matrix. Its formation depends on a redox-sensible signaling that involves de regulation of a number of enzymes, such as the activation of the focal adhesion kinase(FAK), by reactive oxygen species (ROS). In melanoma cells the main source of ROS is Nox4, a subtype of the NADPH oxidase. PDI is a thiol oxidase reductas…

  Role of peri/epicellular disulfide isomerase protein (pecPDI) in cytoskeletal organization and survival of melanoma cells, BP.IC

• Abstract

  NADPH oxidase 4 (Nox4) is an isoform of NADPH oxidase. This family of enzymes is dedicated to the production of reactive oxygen species (ROS) in cells. It is known that, in melanoma cells, the expression and activity of Nox4 are increased when compared to healthy cells and it may influence the proliferation, migration and survival of malign cells. Since melanoma is the most aggressive typ…

  Role of microRNA-9 in control of Nox4 expression and in migration of melanoma cells, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Under physiological conditions, formation of reactive oxygen species (ROS) is counterbalanced by endogenous antioxidant defenses systems. When ROS production exceeds cellular antioxidant capacity, oxidative stress can cause damage to the cell. In normal physiologic conditions, Nox-derived ROS act as second messengers in cell signaling and modulate processes such as gene expression, cell …

  Role of protein disulfide isomerase in the regulation of Nox1 activation and EGFR signaling in cancer, BE.EP.PD

• Abstract

  Oxidative stress in cardiovascular system can lead to diseases including hypertension, atherosclerosis, cardiac hypertrophy, heart failure and restenosis. The primary source of reactive oxygen species (ROS) in vascular cells is NADPH oxidases (Nox) that are a family of seven membrane-integrated catalytic subunits, and regulatory subunits, according with cell type and stimuli. Among these …

  Role of protein disulfide isomerase in the redox regulation of ADAM17 activation and EGFR signaling in vascular disease, BE.EP.PD
• Characterization of the NADPH-binding component of the leukocyte oxidase: identification of the NADPH binding site of P67, BE.PQ