Maria Mitzi Brentani

• Abstract

  Breast cancer is an heterogenous disease that can be classified into sutypes based in gene expression patterns including mainly a luminal group (ER+PR+erbB2-) and a basal like subtype (ER-PR-erbB2-, cytokeratin 5/6 positive) which were correlated with patient outcome. Stromal fibroblasts influence the behavior of breast carcinoma epithelial cells adding one more factor to this complex pro…

  Gene expression profiling of the tumor fibroblasts in breast cancer classified into subtypes by estrogen and progestorone receptors and ERBB-2 status, AP.TEM

• Abstract

  The predominant stromal cell type in breast carcinomas is the fibroblast. These fibroblasts are phenotypically different from their normal counterparts and they present several altered features such as proliferative potential, expression of growth factors and production of different ECM proteins. Moreover tumor environmental is involved in angiogenesis and invasion. Thus, fibroblasts may …

  Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma of the breast, AP.TEM

• Abstract

  The purpose of this study to investigate whether stromal cells present in bone marrow (myofibrobl1asts) of patients with myeloid leukemia (AML) and myelodysplatic syndrome (MDS) have different patterns of gene expression when compared to stromal cells of bone marrow from normal donors. Preliminary studies of our group suggested that patient's cells show different growth characteristics as…

  Molecular aspects of hematopoetic cell-bone morrow stroma interactions, AP.TEM

(Only some records are available in English at this moment)

• Changes in the expression profile of microRNAs in fibroblasts associated with breast compared with those obtained from samples of normal breast tissue, BP.DR
• Genetic and microRNAs patterns analysis to identify biomarker associated to aggressive behavior of breast carcinoma in young women, BP.DR
• Determination of expression patterns of microRNA in young women with Breast Cancer., BP.MS