Abstract
Inactivating mutations of the MKRN3 gene are the most prevalent genetic cause of central precocious puberty. The relationship between mutations in this gene and CPP is due to changes in other hormonal pathways, such as kisspeptin and neurokinin B, which culminate in the early reemergence of GnRH peaks. Considering the prevalence and mechanisms of action, the analysis of the MKRN3 gene is …