Abstract
As the tumor evolves, an immunosuppressive tumor microenvironment (TME) emerges and, as a result, immune cells become dysfunctional and lose the ability to eliminate tumor cells. In this sense, NK cells lose their ability to produce cytotoxic granules and thus become incapable of effectively destroying tumor cells. Immune checkpoint inhibitors (ICI), such as anti-PD1 and anti-CTLA-4, can …