Abstract
Mutations in isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) genes are present in the vast majority of low-grade gliomas and less frequently in glioblastoma, acute myeloid leukemia, cholangiocarcinoma, among others. Aberrant epigenetic reprogramming is a documented feature of cancer and is even more prominent in tumors with mutations in IDH1 and IDH2 (IDH1/2), where an accumulation of glob…