Abstract
RMEL3 (Restricted to Melanoma 3) is a lncRNA enriched in melanoma, especially in association with the BRAFV600E mutation and the invasive phenotype. RNA-protein interaction data obtained in our laboratory support the hypothesis of a role for lncRMEL3 as a positive regulator of BRAFV600E and a negative regulator of the Hippo tumor suppressor pathway. In a global gene expression analysis by…