bachelor's at Farmácia e Bioquímica from Universidade de São Paulo (1980), master's at Biochemistry from Universidade de São Paulo (1985) and doctorate at Biochemistry from Universidade de São Paulo (1988). Has experience in Biochemistry, focusing on Proteins, acting on the following subjects: snake venom, disintegrin, metalloprotease, desintegrina and metaloprotease. (Source: Lattes Curriculum)
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Integrins are heterodimeric cell surface receptors that connect cells to the extracellular matrix (ECM) and control various processes such as cell migration, cytoskeletal organization, cell polarity, metalloprotease activity, collagen synthesis, and migration direction. The pattern of integrin expression may be greatly altered in cells that underwent tumor transformation when compared to …
The extracellular matrix (ECM) is the structural scaffold for body tissues, and it is formed by a complex network of macromolecules such as collagens, glycosaminoglycans and proteoglycans. The ECM supports tissue volume, size and strength, and it is the basis for cell growth, division, and migration. However, ECM function is beyond structural and mechanical support. The ECM actively modul…
(Only some records are available in English at this moment)
Integrins are heterodimeric cell surface receptors that connect cells to the extracellular matrix (ECM) and control diverse processes such as cell migration, cytoskeleton organization and direction of migration. The pattern of integrin expression may be significantly altered in cells that have undergone tumor transformation when compared to that of normal cells. Integrin-mediated signalin…
Breast cancer is a heterogeneous disease with a high incidence in the femalepopulation and with the highest mortality rate among women in Brazil. Tumors thatexpress some type of hormone receptor respond favorably to existing therapies;however, triple-negative tumors, which do not contain them, are difficult to treat. Theinsufficient response of triple-negative tumors to therapeutic resour…
A great part of the total mass in a tumor microenvironment comprises recruited macrophages,which may act in pro- or anti-tumoral responses depending on its interaction with the microenvironment. M2 macrophages are essential for metastatic processes, contributing to a pro-angiogenic and invasive context. In tumor cells, particularly under stress situations such as hypoxia, the communicatio…
Extracellular Vesicles (EV) are structures able to carry biomolecules stably, whose function is mainly of cell-cell communication. During Cancer development, the establishment of hypoxia stimulates the secretion of tumour derived EVs, which will act in all the steps of the metastatic cascade, especially in the communication between cells of the Tumour Microenvironment (TME). Signalling fr…
(Only some records are available in English at this moment)
Extracellular vesicles (EVs) are nano-scaled particles secreted by cells that offer stable transport and storage of biomolecules. Their structure allows them to be taken up by other cells, thus turning EVs as potential candidates for new therapeutical approaches, particularly in drug delivery. To fully comprehend how EVs perform in a therapeutic setting, knowledge on cargo loading mechani…
The ability of cells to adhere to each other and to the extracellular matrix is essential for the formation of tissues and organs. Among the different classes of adhesion molecules, integrins stand out because they bind to proteins associated with cytoskeletal linkage and signaling molecules, promoting mechanical signals. Besides these adhesion molecules are involved in normal cellular fu…
Cancer is a serious human health problem worldwide. Metastasis is responsible for as much as 90% of cancer-associated mortality, and remains as the most poorly understood component of cancer pathogenesis. Tumor cells are capable to proliferate and create a microenviroment, as well as migrate to distant sites by a cross talk with the surrounding environment. In the last years, evidence is …
(Only some records are available in English at this moment)
| 24 / 9 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 50 / 27 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 79 / 41 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID