Alexis de Sá Ribeiro do Bonfim de Melo

CV Lattes Google Scholar Citations

Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal)
Birthplace: Brazil

PhD in Sciences and Master in Microbiology and Immunology both in Dept. of Micro, Immunology and Parasitology of Federal University of São Paulo (UNIFESP). Bachelor in Marine Biology at State University of São Paulo (UNESP). In recent years I studied the role of host cell signaling pathways responsible for the regulation of actin dynamics during invasion of Trypanosoma cruzi extracellular amastigotes (EAs). I am used to techniques such as confocal microscopy, western blotting and overexpression / depletion of proteins by lentiviral transduction. Currently, i am seeking new mediators of actin cytoskeleton during EA host invasion using biochemical techniques coupled to mass spectrometry. Keywords: Trypanosoma cruzi, extracellular amastigotes, actin cytoskeleton, host cell invasion, host cell signaling (Source: Lattes Curriculum)

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Scholarships in Brazil

Completed (most recent)

Abstract
The etiologic agent of Chagas Disease, Trypanosoma cruzi is able to infect professional and non-professional phagocytic cells by mechanisms that depend, among other factors, on the parasite form. While bloodstream trypomastigotes rely on host cell lysosome exocytosis, extracellular amastigotes (AEs), object of our study, mainly depend on the actin cytoskeleton to invade mammalian host cel…
Identification and characterization of novel actin cytoskeleton mediators during host cell invasion by the extracellular amastigote forms of Trypanosoma cruzi, BP.PD
Abstract
Chagas' disease is caused by the flagellated protozoan Trypanosoma cruzi. The extracellular amastigotes (EA) cellular invasion is highly dependent on the actin cytoskeleton of the host cell whose regulation during this specific interaction remains poorly characterized. The Cdc42 and Rac1 GTPases are involved in a variety of in various cellular processes, but mainly in the regulation of th…
The Cdc42/N-WASP and Rac1/WAVE2 pathways regulation of actin dynamics during cellular invasion by extracellular amastigotes of Trypanosoma cruzi, BP.DR
The role of protein kinase D and cortactin in the cellular invasion by extracellular amastigotes of Trypanosoma cruzi, BP.MS

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5 / 3	Completed scholarships in Brazil

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Biological Sciences Biophysics Parasitology

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Abstract

Abstract