CV Lattes
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Sociedade Beneficente de Senhoras (SBSHSL). Hospital Sírio-Libanês (Institutional affiliation from the last research proposal) Birthplace: Brazil
Dr. Mariana Lemos-Duarte, working with Dr. Lakshmi Devi is investigating the role of protein kinases in modulating desensitization by G protein coupled receptors and identifying small molecule ligands targeting orphan G protein coupled receptors. Dr. Lemos-Duarte holds a bachelor?s degree in Pharmaceutical Sciences from Rio de Janeiro Federal University and a master?s degree in Cell Biology from the National Cancer Institute in Brazil and a PhD degree from the Institute of Chemistry at University of Sao Paulo, Brazil. Dr. Lemos-Duarte obtained her postdoctoral training at the Ludwig Cancer Institute, San Diego, CA working with Dr. Karen Oegema, Dr. Arshad Desai and Dr. Andrew Shiau (Small Molecule Discovery Lab) and with Dr. Anamaria Camargo at the Ludwig Cancer Institute, São Paulo, Brazil. Throughout her career, she has been interested in developing new therapeutic strategies for treatment of cancer. (Source: Lattes Curriculum)
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Metastasis, the spreading and the growth of tumor cells in discontinuous anatomic sites from the primary tumor, is the major cause of death for cancer patients. Ironically, on the perspective of tumor biology, mechanisms of action remain among the most obscure events of carcinogenesis. In this project, we intent to continue one line of research that initially appeared in our group, when w…
Aneuploidy, an abnormal balance of chromosomes, is a common feature of solid tumors and is resulting from errors in chromosome segregation. Whether aneuploidy promotes or suppresses tumor initiation and progression is a controversial question, and the identification of new molecular mechanisms that underlie the chromosome segregation is relevant to our full understanding of genetic stabil…
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