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Universidade Federal do ABC (UFABC). Centro de Matemática, Computação e Cognição (CMCC) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Silvia Honda Takada in research grants and scholarships supported by FAPESP.
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Perinatal asphyxia is considered a serious public health concern worldwide, as it causes permanent sequelae, such as motor, cognitive and/or sensory deficits. Furthermore, there are reports that perinatal asphyxia may predispose individuals to autism spectrum disorder (ASD), schizophrenia, attention deficit hyperactivity disorder and, according to more recent studies, there are reports th…
The Federal University of ABC (UFABC) was created on July 26, 2005 (Law n. 11,145). Despite being considered a young universit, it already has considerable infrastructure to support Research activities, characterized by the institutional support office, research integrity office and, in addition, strategies for open access to publications. The support of funding agencies is essential for …
Oxygen deprivation at birth, known clinically as neonatal anoxia or perinatal asphyxia, is considered one of the major causes of neonatal deaths in the world and one of the main risk factors for several neurodevelopmental disorders in individuals who survive this condition, generating considerable impact in public health. One of the main risk groups for the occurrence of neonatal anoxia a…
The Federal University of ABC (UFABC) is one of the new Brazilian federal universities, created by Law 11,145, on July 26, 2005. Although relatively new, the University has infrastructure to support Research activities, characterized by the institutional support office, research integrity office and, in addition, has strategies for open access publications. Even so, support from funding a…
(Only some records are available in English at this moment)
Maternal immune activation is a major cause of premature births, and preterm newborns are at high risk of complications such as perinatal asphyxia. Combined, these two "inflammatory hits" can cause neurodevelopmental impairment and lead to disorders such as autism spectrum disorder. Perineuronal networks are crucial for the maturation of inhibitory interneurons and appear to be directly i…
Perinatal asphyxia, characterized by hypoxemia, hypercapnia, and acidosis, results from the partial or total interruption of oxygen supply, which may or may not be associated with ischemia, leading to hypoxic-ischemic brain injuries with a high incidence in premature newborns. Among survivors, 25% exhibit permanent neurological sequelae, such as learning difficulties, ADHD, and motor and …
Hypoxia is defined as a decrease in tissue O2 concentration and ischemia as a decrease in blood flow to the tissue which, in turn, prevents the adequate distribution of O2, glucose and other nutrients. Hypoxia is one of the most potent stimulators of vascular endothelial growth factor (VEGF). Hypoxic-ischemic encephalopathy, mainly resulting from oxygen deprivation at birth, whose clinica…
Neonatal anoxia is defined as total deprivation of oxygen supply at birth and its incidence in low-birth-weight preterm infants is approximately 60%. One of the experimental models developed to study this condition is the neonatal anoxia model, global and non-invasive, which has the advantage of simulating clinical conditions of premature newborns. In this model, death was observed in the…
Prematurity is characterized by the births before the 37 week, and extreme cases of prematurity, before the 24 week, are the more fatal to neonates. Due to the immunological and pulmonary immaturity of extremely preterm neonates, inflammation and neonatal asphyxia are among the most common complications. When combined with asphyxia, neonatal inflammation potentiates brain injuries and exa…
Neonatal anoxia is a worldwide public health problem, that affects term and preterm newborns. It consists of oxygen privation that results in neurological consequences. Currently, the only known therapy is hypothermia, which is not effective in all cases. Therefore, an experimental model of global and non-invasive neonatal anoxia simulates clinical conditions of preterm newborns to invest…
(Only some records are available in English at this moment)
Perinatal asphyxia is an important public health problem worldwide, caused by a decrease in tissue O2 concentration and reduced blood flow to the tissue. Due to the high energy demand, the brain is particularly susceptible to asphyxia and the resulting injury is called hypoxic-ischemic encephalopathy (HIE). HIE affects 3 out of every 1000 full-term newborns, with a higher incidence in pre…
Perinatal asphyxia is a worldwide public health problem, affecting both full-term and preterm newborns, and is one of the leading causes of neonatal deaths worldwide and a cause of severe and irreversible neurological damage in individuals who survive.Currently, the only existing therapy is therapeutic hypothermia, which is ineffective in all cases. In the premature population, therapeuti…
Preterm infants are at high risk for later cognitive and behavioral deficits. Microbial community in infant guts, or microbiota, is acquired from the environment at birth and interacts to the maturing immune system. Perturbing initial colonization and microbiota development can affect brain development and post risk of developing neurological disorders later in life. Accumulating evidence…
Hypoxia-ischemia can lead to serious and long lasting consequences and is one of the major causes of brain injury in neonates. Cerebral palsy, one of the most important sequelae of hypoxia-ischemia, has a high incidence that deserves special attention. The difficulty in finding a proper animal model that mimics cerebral palsy is a limiting factor for better understanding this condition. I…
| 1 / 1 | Ongoing grants |
| 6 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 9 / 8 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 23 / 22 | All research grants and scholarships |
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