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Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia Elétrica e de Computação (FEEC) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Leonardo Abdala Elias is an Assistant Professor at the Department of Electronics and Biomedical Engineering, School of Electrical and Computer Engineering, University of Campinas (UNICAMP, Brazil). Also, he is an Associate Researcher and current Director of the Center for Biomedical Engineering, UNICAMP. He is the founder and current Head of the Neural Engineering Research Laboratory (NER Lab). His research in Neural Engineering focuses on theoretical/computational and experimental investigations that aimed at understanding how different elements of the neuromusculoskeletal system interact during normal and pathological control of human movement. Dr. Elias received the BS in Electrical Engineering from the Federal University of Goias (Goiania, Brazil) in 2008, and the MS and PhD in Biomedical Engineering both from the University of Sao Paulo (Sao Paulo, Brazil) in 2010 and 2013, respectively. He was a Post-Doctoral Fellow at the Biomedical Engineering Lab, University of Sao Paulo (2013-2014), and a Visiting Researcher at the Department of Neurorehabilitation Engineering, Georg-August University (Goettingen, Germany, 2015). He is member of the International MotoNeuron Society, and the Brazilian Society of Biomedical Engineering. (Source: Lattes Curriculum)
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The neurophysiological control of muscle force comprises a complex interplay between elements of the nervous, muscular and skeletal systems. From a neurophysiological standpoint, the activity of motor units and sensory afferents are of paramount importance to shape the motor output during the execution of different tasks. In this research project, the neurophysiological control of muscle …
Decomposition of surface High-Density Electromyographic signals (HD EMG) into motor unitspike trains opens a non-invasive window to neural mechanisms underlying movement control. The signals produced by EMG decomposition have a scientific (to understand the physiology of motor system) and technological (to the control of human-machine interfaces, such as myoelectric prosthesis) relevance.…
Studies on the neurophysiological control of muscle force have used correlation analysis to understand the functional coupling between different structures of the nervous system during a motor task. The assumption behind these techniques is that the relations between the experimentally recorded variables [e.g., electroencephalogram (EEG), surface electromyogram (sEMG), motor unit activity…
Mathematical modeling and computer simulations have been used to study the functioning of the human neuromuscular system. The advantage of these approaches is that one can comprehensively investigate how cellular and molecular mechanisms would influence motor behaviors observed at a macroscopic scale, for instance, the generation of muscle force and electromyogram. However, few studies ha…
Parkinson's disease (PD) has been postulated to result from degeneration of dopaminergic neurons in the basal ganglia. The main symptoms of this neurodegenerative disease are: tremor, difficulty in the maintenance of posture, and uncoordinated movements. Parkinsonian tremor is thought to emerge from increased cortical oscillations, especially in alpha (8-15Hz) and beta (15-35Hz) bands. Th…
The H (Hoffman) reflex is a noninvasive technique used to evaluate the synaptic organization of the spinal cord, as well as the excitability of the reflex arc. In this procedure, percutaneous electrical stimuli are applied to the peripheral nerve to evoke reflex responses that can be measured by the electromyogram of the target muscle. Different factors can modulate the H-reflex amplitude…
Mathematical modeling and computer simulations have been widely used in the neural sciences to provide theoretical/conceptual foundations on the mechanisms involved in the functioning of the nervous system. Specifically, mathematical models of alpha motor neurons (MNs) have supported investigations on the dynamical behavior of individual cells under different experimental conditions. Also…
(Only some records are available in English at this moment)
The performance of a given motor task is largely influenced by the neural drive to the muscles, which is provided by the spinal motor neurons (MNs). Therefore, the way these MNs integrate a plethora of neural signals from different sources is determinant to mold the motor output. One factor that is known to influence the force control is the degree of synchronism (or correlation) between …
| 2 / 2 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 6 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 12 / 12 | All research grants and scholarships |
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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 11 |
| Citations | 79 |
| Cit./Article | 7.2 |
| Data from Web of Science | |
LEONARDO ABDALA ELIAS; DÉBORA ELISA DA COSTA MATOSO; RENATO NAVILLE WATANABE; ANDRÉ FABIO KOHN. Perspectives on the modeling of the neuromusculoskeletal system to investigate the influence of neurodegenerative diseases on sensorimotor control. Res. Biomed. Eng., v. 34, n. 2, p. -, Jun. 2018. (15/14917-9, 17/11464-9, 15/21819-3)
. Perspectives on the modeling of the neuromusculoskeletal system to investigate the influence of neurodegenerative diseases on sensorimotor control. Res. Biomed. Eng., n. ahead, p. -, 2018. (15/14917-9, 17/11464-9, 15/21819-3)
NAKAJIMA, TSUYOSHI; TAZOE, TOSHIKI; SAKAMOTO, MASANORI; ENDOH, TAKASHI; SHIBUYA, SATOSHI; ELIAS, LEONARDO A.; MEZZARANE, RINALDO A.; KOMIYAMA, TOMOYOSHI; OHKI, YUKARI. Reassessment of Non-Monosynaptic Excitation from the Motor Cortex to Motoneurons in Single Motor Units of the Human Biceps Brachii. FRONTIERS IN HUMAN NEUROSCIENCE, v. 11, JAN 30 2017. Web of Science Citations: 6. (09/15802-0, 13/10433-1, 12/05304-5)
MAGALHAES, FERNANDO HENRIQUE; ELIAS, LEONARDO ABDALA; DA SILVA, CRISTIANO ROCHA; DE LIMA, FELIPE FAVA; DE TOLEDO, DIANA REZENDE; KOHN, ANDRE FABIO. D1 and D2 Inhibitions of the Soleus H-Reflex Are Differentially Modulated during Plantarflexion Force and Position Tasks. PLoS One, v. 10, n. 11, NOV 24 2015. Web of Science Citations: 4. (13/10433-1, 12/09321-1, 13/14667-7, 11/17193-0, 11/13222-6)
WATANABE, RENATO N.; MAGALHAES, FERNANDO H.; ELIAS, LEONARDO A.; CHAUD, VITOR M.; MELLO, EMANUELE M.; KOHN, ANDRE F.. Influences of premotoneuronal command statistics on the scaling of motor output variability during isometric plantar flexion. Journal of Neurophysiology, v. 110, n. 11, p. 2592-2606, DEC 2013. Web of Science Citations: 13. (13/10433-1, 10/12934-0, 09/15802-0, 11/21103-7, 11/13222-6)
RANIERI, CAETANO M.; PIMENTEL, JHIELSON M.; ROMANO, MARCELO R.; ELIAS, LEONARDO A.; ROMERO, ROSELI A. F.; LONES, MICHAEL A.; ARAUJO, MARIANA F. P.; VARGAS, PATRICIA A.; MOIOLI, RENAN C.. A Data-Driven Biophysical Computational Model of Parkinson's Disease Based on Marmoset Monkeys. IEEE ACCESS, v. 9, p. 122548-122567, 2021. Web of Science Citations: 0. (13/07375-0, 17/02377-5, 18/25902-0, 18/11075-5)
GERMER, CARINA M.; FARINA, DARIO; ELIAS, LEONARDO A.; NUCCIO, STEFANO; HUG, FRANCOIS; DEL VECCHIO, ALESSANDRO. Surface EMG cross talk quantified at the motor unit population level for muscles of the hand, thigh, and calf. Journal of Applied Physiology, v. 131, n. 2, p. 808-820, AUG 2021. Web of Science Citations: 0. (17/22191-3)
ELIAS, LEONARDO ABDALA; KOHN, ANDRE FABIO. Individual and collective properties of computationally efficient motoneuron models of types S and F with active dendrites. Neurocomputing, v. 99, p. 521-533, JAN 1 2013. Web of Science Citations: 7. (09/15802-0, 07/05898-4)
LEONARDO ABDALA ELIAS; ANDRÉ FABIO KOHN. Web-based neuromuscular simulator applied to the teaching of principles of neuroscience. Rev. Bras. Eng. Bioméd., v. 29, n. 3, p. 213-226, Set. 2013. (09/15802-0)
ELIAS, LEONARDO ABDALA; WATANABE, RENATO NAVILLE; KOHN, ANDRE FABIO. Spinal Mechanisms May Provide a Combination of Intermittent and Continuous Control of Human Posture: Predictions from a Biologically Based Neuromusculoskeletal Model. PLOS COMPUTATIONAL BIOLOGY, v. 10, n. 11, NOV 2014. Web of Science Citations: 24. (09/15802-0, 11/21103-7)
ELIAS, LEONARDO ABDALA; CHAUD, VITOR MARTINS; KOHN, ANDRE FABIO. Models of passive and active dendrite motoneuron pools and their differences in muscle force control. Journal of Computational Neuroscience, v. 33, n. 3, p. 515-531, DEC 2012. Web of Science Citations: 18. (09/15802-0)
MEZZARANE, RINALDO ANDRE; MAGALHAES, FERNANDO HENRIQUE; CHAUD, VITOR MARTINS; ELIAS, LEONARDO ABDALA; KOHN, ANDRE FABIO. Enhanced D1 and D2 Inhibitions Induced by Low-Frequency Trains of Conditioning Stimuli: Differential Effects on H- and T-Reflexes and Possible Mechanisms. PLoS One, v. 10, n. 3, MAR 25 2015. Web of Science Citations: 7. (13/10433-1, 09/15802-0, 10/15522-4, 11/17193-0, 11/13222-6)
GERMER, CARINA MARCONI; MOREIRA, LUCIANA SOBRAL; ELIAS, LEONARDO ABDALA. Sinusoidal vibrotactile stimulation differentially improves force steadiness depending on contraction intensity. MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, v. 57, n. 8, p. 1813-1822, AUG 2019. Web of Science Citations: 0. (17/22191-3)
GERMER, CARINA MARCONI; DEL VECCHIO, ALESSANDRO; NEGRO, FRANCESCO; FARINA, DARIO; ELIAS, LEONARDO ABDALA. Neurophysiological correlates of force control improvement induced by sinusoidal vibrotactile stimulation. JOURNAL OF NEURAL ENGINEERING, v. 17, n. 1, FEB 2020. Web of Science Citations: 0. (17/22191-3)
(References retrieved automatically from State of São Paulo Research Institutions)
ELIAS, Leonardo Abdala. Estudo por simulação computacional de modelos de motoneurônios com dendrito ativo em resposta a entradas sinápticas.. Dissertação (Mestrado) - Escola Politécnica. Universidade de São Paulo (USP). São Paulo. (07/05898-4)
ELIAS, Leonardo Abdala. Modelagem e simulação do sistema neuromuscular responsável pelo controle do torque gerado na articulação do tornozelo.. Tese (Doutorado) - Escola Politécnica. Universidade de São Paulo (USP). São Paulo. (09/15802-0)
MATOSO, Débora Elisa da Costa. Modelagem computacional de neurônios motores inferiores para o estudo de alterações biofísicas decorrentes da esclerose lateral amiotrófica. Dissertação (Mestrado) - Faculdade de Engenharia Elétrica e de Computação (FEEC). Universidade Estadual de Campinas (UNICAMP). (15/14917-9)