graduate at Medicina from Faculdade de Ciências Médicas da Santa Casa de Misericórdia de São Paulo (1972), master's at Physiology from Universidade de São Paulo (1976) and ph.d. at Psicofarmacologia Setor de Psicobiologia from Universidade Federal de São Paulo (1978). Has experience in Pharmacology, focusing on Neuropsicopharmacology, acting on the following subjects: sono, paradoxical sleep deprivation, polysomnography, sleep and melatonin. (Source: Lattes Curriculum)
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Sleep loss can induce a variety of serious problems, which have been largely neglected as objects of study. As an example, it is estimated obstructive sleep apnea occurs in 2% of children between the ages of 4 and 7; the resulting sleep loss may lead to significant behavioral and cognitive def including leaning problems in school. In the work place, a significant number of accidents invol…
Sleep disturbances in individuals with neurodevelopmental disorders are highly frequent, affecting up to 86% of patients. There is an overlap between the genetic factors that increase risk for both NDDs and sleep disturbances, indicating a common molecular root for this comorbidity. The GRIN2A gene encodes a subunit of NMDA receptors, glutamate- and voltage-dependent ion channels in gluta…
The circadian rhythm, which follows a cyclic pattern of approximately 24 hours, plays a fundamental role in glucose metabolism and insulin sensitivity regulation. Exposure to light and darkness is one of the main factors synchronizing the circadian cycle with the 24-hour environmental cycle. It is known that the circadian rhythm in humans exhibits a phenotypic presentation, determining th…
Sleep is essential to maintain an individual's health and well-being. Sleep disturbances, such as Obstructive Sleep Apnea (OSA), are associated with other disorders. Recently, the participation of sleep and its alterations in pathways related to Cancer development has been suggested. Cancer is one of the most significant health problems in the world and Prostate Cancer is the most prevale…
Obstructive Sleep Apnea (OSA) is a highly prevalent and morbid sleep disorder. Among the factors associated with its pathophysiology, the role of intermittent hypoxia stands out, contributing to the development of oxidative stress and inflammation. It is known that cumulative levels of these factors negatively influence the final portion of the DNA, known as telomere. In this sense, we hy…
Sleep is one of the most important physiological processes for the healthy maintenance of many organisms. Significant alterations in sleep patterns and the quantity and quality of sleep are found as people get older. Besides, the elderly population has been found to have a higher prevalence of sleep disturbances. Concurrently with increasing age, there is also the shortening of telomeres,…
The increase in life expectancy in the last decades has resulted in a scenario in which the elderly constitutes a growing proportion of the population. Several studies have targeted the population aging, and those which aims at the identification of molecular mechanisms and behaviors associated with successful aging are more and more evident. Some physiological patterns and lifestyle habi…
(Only some records are available in English at this moment)
| 8 / 1 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 44 / 15 | Completed scholarships in Brazil |
| 55 / 19 | All research grants and scholarships |
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CV Lattes
ORCID