CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Faculdade de Odontologia (FOAr) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences from the State University of Campinas (1997), Master in Pathology Oral-Dental Biology from the State University of Campinas (2000), PhD in Oral-Dental Biology from the State University of Campinas (2002) and Postdoctoral Fellow in Mutagenesis the Faculty of Medicine of Ribeirão Preto, FMRP-USP (2010). Currently, I am working as Adjunct Professor in the School of Dentistry at Araraquara - UNESP, Univ Estadual Paulista, responsible for teaching Human Genetics. Have experience in dentistry, with emphasis on Genetics Susceptibility to Periodontal Disease with or without Diabetes and Dyslipidemia, particularly investigating: genetic polymorphisms and their functionality, gene expression, Immunogenetics, dysmorphology and Down Syndrome. As a new line of research I have been investigating cytotoxicity, genotoxicity and mutagenicity of Biomaterials. E-mail contact: raquel@foar.unesp.br (Source: Lattes Curriculum)
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Type 2 Diabetes Mellitus (T2DM) and Periodontitis (P) are multifactorial pathologies mediated by a polygenic system that leads to exacerbation of the immune response. It is recognized that T2DM influences the degree of periodontitis. However, in the presence of T2DM, the longitudinal effect of periodontal treatment on the levels of important molecules of the immune system is not well know…
It has been more frequent to find patients affected by the combination of Type 2 Diabetes Mellitus (T2DM), Dyslipidemia and Periodontitis (P). There is increasing evidence in the literature in demonstrating interactions between T2DM, dyslipidemia, immune system alterations and Periodontitis. For a better understanding of such interactions, studies with animal models, mainly murine, have b…
The present application is intended to enable the visit of the Researcher Dr. Jeronimo C. Ruiz, Principal Researcher of the Oswaldo Cruz Foundation (RENE RACHOU Institute - IRR, Belo Horizonte, MG) to the School of Dentistry of Araraquara - FOAr UNESP to enable collaboration in the Bioinformatics area of 4 main projects (and others related) of the Responsible Researcher Dr. Raquel M.Scare…
Although evidences show association of polymorphisms in cytokine genes with susceptibility to chronic periodontitis (CP), there are many genes (e.g metabolism) that may affect the pathogenesis of PC that have not yet been investigated. Therefore, further studies are needed to identify polymorphisms associated with periodontal disease (PD) which can be used as genetic markers of PD in our …
(Only some records are available in English at this moment)
It is well established that Type 2 Diabetes Mellitus (T2DM) influences Periodontitis (P). However, in the presence of T2DM, the longitudinal effect of periodontal treatment on key immune system molecules remains unclear or contradictory, as does its potential modulation by systemic glycemic control. Supported by FAPESP, one of our recent findings was a gradual reduction in the gene (syste…
It is becoming increasingly common to find patients affected by type 2 diabetes mellitus (T2DM) combined with dyslipidemia and periodontitis. There is growing evidence in the literature demonstrating the relationship between T2DM, dyslipidemia, immune system disorders, and periodontitis. To better understand this relationship, as well as the relationship between oral health and systemic h…
The incidence of patients affected simultaneously by Type 2 Diabetes Mellitus (T2DM), Dyslipidemia and Periodontitis (P) is increasing. Also increases the evidence in the literature demonstrating interactions among these pathologies, mediated by immune system dysfunction and higher glyco-oxidative stress. In order to contribute, our research group is developing the project "Morpho-functio…
Type 2 Diabetes Mellitus (DM2) and Periodontitis (P) are two diseases that have been increasingly common in patients at the present time. Periodontitis is a multifactorial immunoinflammatory disorder mediated by the host in response to microbial dysbiosis, and has been recognized as the sixth major complication associated with T2DM, as a greater extent and severity of Periodontitis was de…
It has been found more frequently patients affected by a combination of Type 2 Diabetes Mellitus (T2DM), Dyslipidemia, and Periodontitis (P). Evidence in the literature is increasing in demonstrating interactions between T2DM, Dyslipidemia, immune system dysfunction, and Periodontitis. For a better understanding of such interactions, and to know molecules with a key role on them, it is va…
(Only some records are available in English at this moment)
Molar-Incisor Hypomineralization (MIH) is an enamel defect of systemic origin that affects one or more permanent primary molars, and may or may not be associated with the permanent incisors. From the etiological point of view, this condition may be considered multifactorial and complex. Recently, genetic variants such as polymorphisms and some genes related for enamel formation were assoc…
Many studies around the world have investigated genetic polymorphisms associated with susceptibility to periodontal disease (PD), but more studies are need to know risk factors to chronic periodontitis (CP) in the Brazilian population, mainly because its miscegenation. Moreover, there are few studies focused on identifying biological functionality of polymorphisms in the context of PD. Th…
The aim of this study is to investigate the salivary and plasma proteome related to individuals affected by type 2 Diabetes Mellitus (DM2, metabolically compensated/decompensated), Dyslipidemia and Chronic Periodontal Disease (DP). The development of this study proposes to complement the recently completed PhD study from the requestor (FAPESP 2009/16233-9 and 2010/10882-2) in which five g…
| 1 / 1 | Ongoing grants |
| 10 / 10 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 30 / 25 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 46 / 41 | All research grants and scholarships |
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