CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
She graduated in Chemistry from UNESP (2008), holds a Master's (2010) and a Ph.D. (2014) in Inorganic and Analytical Chemistry from USP-São Carlos. She completed a Postdoctoral in Biochemistry at USP-São Paulo (2017) and a Postdoctoral in Bioinorganic Chemistry at the University of California, Santa Barbara (2018).She was the winner of the Women in Science Program, promoted by L'Oréal Brazil in partnership with UNESCO in Brazil and the Brazilian Academy of Sciences (ABC) in the Chemical Sciences category in 2020.She is currently a Professor in the Department of Biochemistry at the University of São Paulo (IQ-USP), where she works in the field of bioinorganic chemistry, with an emphasis on redox processes promoted by nitric oxide and the reactivity of iron nitrosyl complexes. (Source: Lattes Curriculum)
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Nitric oxide (NO) is a signaling molecule that plays roles in physiological and pathological processes. Among its capabilities, NO can act as an efficient cellular iron sequester forming dinitrosyl iron complexes (DNICs) and reducing oxidative stress from Fenton chemistry. This process may play important roles in a variety of pathologies associated with oxidative stress such as neurodegen…
Nitric oxide (NO) is a signaling molecule that plays roles in physiological and pathological processes. Among its capabilities, NO can act as an efficient cellular iron sequester forming dinitrosyl iron complexes (DNICs) and reducing oxidative stress from Fenton chemistry. This process may play important roles in a variety of pathologies associated with oxidative stress such as neurodegen…
Nitric oxide (NO) is an inorganic neutral radical molecule produced endogenously through reaction catalyzed by the nitric oxide synthase (NOS) family of enzymes. In cells, NO participates in pathophysiological processes by reacting selectively with other radicals and transition metals. Among the main NO biological targets are superoxide anion radical (O2*-) and iron metal centers. The rea…
Currently, all studies of biological DNICs use Electron Paramagnetic Resonance (EPR) for their detection and quantification. However, the EPR technique has limitations for DNICs studies such as the high limit of detection and quantification and the lack of detection of the binuclear form of DNICs. Additionally, Saville's method, which is widely used for quantification of NO-metabolites (n…
Thioredoxin (Trx), a ubiquitous protein in organisms, exhibits a highly conserved active site in which two cysteines are separated in the primary structure only by two amino acid residues (CXXC). These cysteine residues can be in the oxidized (disulfide, S-S) or the reduced state (thiols, SH) and enable the Trx function in hydrogen peroxide (H2O2) metabolism and a diversity of interaction…
Dinitrosyl iron complexes (DNICs, [Fe(NO)2(L)2]-) are important NO-metabolites. Recently, we elucidated the formation mechanism of DNICs containing low molecular weight thiols. Thereby, we verify that the formation of {Fe(NO)2}9 moiety found in DNICs involves the reduction of Fe2+ to Fe+ promoted by low molecular weight thiols, which is in accordance with their function as biological redu…
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Nitric oxide (NO*) plays key roles in both physiological and pathological processes, with its most abundant metabolite being dinitrosyl iron complexes (DNICs). Studies show that synthetic DNICs mediate functions like vasodilation, platelet aggregation, and carcinogenesis inhibition. In addition, the endogenous generation of DNICs have been correlated to reduction of cellular oxidative str…
High molecular weight dinitrosyl iron complexes (DNICs) have been consistently detected in cell and tissues in situations of nitric oxide overproduction since 1965. Despite this fact, the structures of biological DNICs remain unknown whereas the reactivity of synthetic DNICs received limited attention in the literature. Biological DNICs have been proposed to act as nitric oxide reservoirs…
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| 6 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 11 / 11 | All research grants and scholarships |
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