Daniela Ramos Truzzi in research grants and scholarships supported by FAPESP.
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Nitric oxide (NO) is a signaling molecule that plays roles in physiological and pathological processes. Among its capabilities, NO can act as an efficient cellular iron sequester forming dinitrosyl iron complexes (DNICs) and reducing oxidative stress from Fenton chemistry. This process may play important roles in a variety of pathologies associated with oxidative stress such as neurodegen…
Nitric oxide (NO) is a signaling molecule that plays roles in physiological and pathological processes. Among its capabilities, NO can act as an efficient cellular iron sequester forming dinitrosyl iron complexes (DNICs) and reducing oxidative stress from Fenton chemistry. This process may play important roles in a variety of pathologies associated with oxidative stress such as neurodegen…
Thioredoxin (Trx), a ubiquitous protein in organisms, exhibits a highly conserved active site in which two cysteines are separated in the primary structure only by two amino acid residues (CXXC). These cysteine residues can be in the oxidized (disulfide, S-S) or the reduced state (thiols, SH) and enable the Trx function in hydrogen peroxide (H2O2) metabolism and a diversity of interaction…
Dinitrosyl iron complexes (DNICs, [Fe(NO)2(L)2]-) are important NO-metabolites. Recently, we elucidated the formation mechanism of DNICs containing low molecular weight thiols. Thereby, we verify that the formation of {Fe(NO)2}9 moiety found in DNICs involves the reduction of Fe2+ to Fe+ promoted by low molecular weight thiols, which is in accordance with their function as biological redu…
Nitric oxide (NO) participates in several biological functions such as vasodilation, antioxidant action, and neurotransmission. Despite being a radical, in a biological environment, NO reacts specifically with radicals and metals. The reactions between NO and radicals or heme iron centers are well established, while the reactions between NO and non-heme iron centers are less known despite…
In addition to be involved in cell and tissue damage, oxidants are presently recognized to participate in signaling mechanisms. Part of the redox signaling responses occur through reversible modifications of cysteine residues in proteins. For instance, hydrogen peroxide reacts directly with specific cysteine thiols (-SH) in proteins to form sulfenic acid derivatives (-SOH) and these proce…
High molecular weight dinitrosyl iron complexes (DNICs) have been consistently detected in cell and tissues in situations of nitric oxide overproduction since 1965. Despite this fact, the structures of biological DNICs remain unknown whereas the reactivity of synthetic DNICs received limited attention in the literature. Biological DNICs have been proposed to act as nitric oxide reservoirs…
| 2 / 2 | Ongoing research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 3 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 8 / 8 | All research grants and scholarships |
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